Por favor, use este identificador para citar o enlazar este ítem: http://hdl.handle.net/10637/12939
Título : Fructose during pregnancy provokes fetal oxidative stress : the key role of the placental heme oxygenase-1.
Autor : Rodríguez, Lourdes.
Bocos de Prada, Carlos.
Panadero Antón, María Isabel.
Rodrígo, Silvia.
Materias: FructosePregnancyOxidative stressHeme oxygenase-1Placenta
Fecha de publicación : 10-ago-2016
Resumen : Scope: One of the features of metabolic syndrome caused by liquid fructose intake is an impairment of redox status. We have investigated whether maternal fructose ingestion modifies the redox status in pregnant rats and their fetuses. Methods and results: Fructose (10% wt/vol) in the drinking water of rats throughout gestation, leads to maternal hepatic oxidative stress. However, this change was also observed in glucose-fed rats and, in fact, both carbohydrates produced a decrease in antioxidant enzyme activity. Surprisingly, mothers fed carbohydrates displayed low plasma lipid oxidation. In contrast, fetuses from fructose-fed mothers showed elevated levels of plasma lipoperoxides versus fetuses from control or glucose-fed mothers. Interestingly, a clearly augmented oxidative stress was observed in placenta of fructose-fed mothers, accompanied by a lower expression of the transcription factor Nuclear factor-erythroid 2-related factor-2 (Nrf2) and its target gene, heme oxygenase-1 (HO-1), a potent antioxidant molecule. Moreover, histone deacetylase 3 (HDAC3) which has been proposed to upregulate HO-1 expression by stabilizing Nrf2, exhibited a diminished expression in placenta of fructose-supplemented mothers. Conclusions: Maternal fructose intake provoked an imbalanced redox status in placenta and a clear diminution of HO-1 expression, which could be responsible for the augmented oxidative stress found in their fetuses.
Descripción : Artículo en colaboración: Lourdes Rodríguez, Paola Otero, María I. Panadero, Antonia García, Coral Barbas, Núria Roglans, Sonia Ramos, Luis Goya, Juan C. Laguna, Juan J. Álvarez-Millán, and Carlos Bocos
En: Molecular Nutrition and Food Research. 2016. vol. 60 (12) : 2700-2711 p. e-ISSN 1613-4133
URI : http://hdl.handle.net/10637/12939
Derechos: http://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
Otros identificadores : 000000723162
Aparece en las colecciones: Facultad de Farmacia

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