Por favor, use este identificador para citar o enlazar este ítem: http://hdl.handle.net/10637/12937
Título : Fructose only in pregnancy provokes hyperinsulinemia, hypoadiponectinemia and impaired insulin signaling in adult male, but not female, progeny.
Autor : Rodríguez, Lourdes.
Bocos de Prada, Carlos.
Panadero Antón, María Isabel.
Materias: Fructose pregnancyFetal programmingMetabolic syndrome.
Fecha de publicación : 10-ago-2016
Resumen : Purpose Fructose intake from added sugars correlates with the epidemic rise in metabolic syndrome and cardiovascular diseases. However, consumption of beverages containing fructose is allowed during gestation. Recently, we found that an intake of fructose (10% 5 wt/vol) throughout gestation produces impaired fetal leptin signaling and hepatic steatosis. Therefore, we have investigated whether fructose intake during pregnancy produces subsequent changes in the progeny, when adult. 8 Methods Fed 261-day-old male and female descendants from fructose-fed, control or glucose9 fed mothers were used. Plasma was used to analyze glucose, insulin, leptin, and adiponectin. Hepatic expression of proteins related to insulin signaling was determined. Results Fructose intake throughout pregnancy did not produce alterations in the body weight of the progeny. Adult male progeny of fructose-fed mothers had elevated levels of insulin without a parallel increase in phosphorylation of protein kinase-B. However, they displayed an augmented serine phosphorylation of insulin receptor substrate-2, indicating reduced insulin signal transduction. In agreement, adiponectin levels, which have been positively related to insulin sensitivity, were lower in male descendants from fructose-fed mothers than in the other two groups. Furthermore, mRNA levels for insulin-responsive genes were not affected (phosphoenol pyruvate carboxykinase, glucose-6-phosphatase) or they were decreased (sterol response element-binding protein-1c) in the livers of male progeny from fructose-supplemented rats. On the contrary, adult female rats from fructose-fed mothers did not exhibit any of these disturbances. Conclusion Maternal fructose, but not glucose, intake confined to the prenatal stage provokes impaired insulin signal transduction, hyperinsulinemia, and hypoadiponectinemia in adult male, but not female, progeny.
Descripción : Artículo en colaboración: María I. Panadero, Núria Roglans, Paola Otero, Silvia Rodrigo, Juan J. Álvarez-Millán, Juan C. Laguna, and Carlos Bocos
En: European Journal of Nutrition. 2016. vol. 55 : 665-674 p. e-ISSN 1436-6215
URI : http://hdl.handle.net/10637/12937
Derechos: http://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
Otros identificadores : 000000723160
Aparece en las colecciones: Facultad de Farmacia

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