Por favor, use este identificador para citar o enlazar este ítem: http://hdl.handle.net/10637/12936
Título : Maternal, fructose intake induces insulin resistance and oxidative stress in male, but not female, offspring.
Autor : Rodríguez, Lourdes.
Bocos de Prada, Carlos.
Panadero Antón, María Isabel.
Materias: Maternal fructose intakeInsulin resistanceOxidative stress in male
Fecha de publicación : 10-ago-2015
Resumen : Objective. Fructose intake from added sugars correlates with the epidemic rise in metabolic syndrome and cardiovascular diseases. However, consumption of beverages containing fructose is allowed during gestation. Recently, we found that an intake of fructose (10% wt/vol) throughout gestation produces an impaired fetal leptin signalling. Therefore, we have investigated whether maternal fructose intake produces subsequent changes in their progeny. Methods. Blood samples from fed and 24 h fasted female and male 90- day-old rats born from fructose-fed, glucose-fed, or control mothers were used. Results. After fasting, HOMA-IR and ISI (estimates of insulin sensitivity) were worse in male descendents from fructose-fed mothers in comparison to the other two groups, and these findings were also accompanied by a higher leptinemia. Interestingly, plasma AOPP and uricemia (oxidative stress markers) were augmented in male rats from fructose-fed mothers compared to the animals from control or glucose-fed mothers. In contrast, female rats did not show any differences in leptinemia between the three groups. Further, insulin sensitivity was significantly improved in fasted female rats from carbohydrate-fed mothers. In addition, plasma AOPP levels tended to be diminished in female rats from carbohydrate-fed mothers. Conclusion. Maternal fructose intake induces insulin resistance, hyperleptinemia, and plasma oxidative stress in male, but not female, progeny.
Descripción : Artículo en colaboración: Paola Otero, María I. Panadero, Silvia Rodrigo, Juan J. Álvarez-Millán and Carlos Bocos
En: Journal of Nutrition and Metabolism. 2015. vol. 2015 : 8 p. e-ISSN 2090-0724
URI : http://hdl.handle.net/10637/12936
Derechos: http://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
Otros identificadores : 000000723159
Aparece en las colecciones: Facultad de Farmacia

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