Por favor, use este identificador para citar o enlazar este ítem: http://hdl.handle.net/10637/12713
Título : Flexible use of allocentric and egocentric spatial memories activates differential neural networks in mices
Autor : Rinaldi, Arianna.
De Leonibus, Elvira.
Cifra, Alessandra.
Torromino, Giulia.
Minicocci, Elisa.
De Sanctis, Elisa.
López Pedrajas, Rosa María.
Materias: Memory.Redes neuronales (Neurobiología)Memoria.Neurobiology.Neurobiología.Neural networks (Neurobiology)
Fecha de publicación : 9-jul-2020
Editorial : Nature Research.
Citación : Rinaldi, A., De Leonibus, E., Cifra, A., Torromino, G., Minicocci, E., De Sanctis, E. et al. (2020). Flexible use of allocentric and egocentric spatial memories activates differential neural networks in mice. Scientific Reports, vol. 10, art. 11338 (09 jul.). DOI: https://doi.org/10.1038/s41598-020-68025-y
Resumen : Goal-directed navigation can be based on world-centered (allocentric) or body-centered (egocentric) representations of the environment, mediated by a wide network of interconnected brain regions, including hippocampus, striatum and prefrontal cortex. The relative contribution of these regions to navigation from novel or familiar routes, that demand a different degree of flexibility in the use of the stored spatial representations, has not been completely explored. To address this issue, we trained mice to find a reward relying on allocentric or egocentric information, in a modified version of the cross-maze task. Then we used Zif268 expression to map brain activation when well-trained mice were required to find the goal from a novel or familiar location. Successful navigation was correlated with the activation of CA1, posterior-dorsomedial striatum, nucleus accumbens core and infralimbic cortex when allocentric-trained mice needed to use a novel route. Allocentric navigation from a familiar route activated dorsomedial striatum, nucleus accumbens, prelimbic and infralimbic cortex. None of the structures analyzed was significantly activated in egocentric-trained mice, irrespective of the starting position. These data suggest that a flexible use of stored allocentric information, that allows goal finding even from a location never explored during training, induces a shift from fronto-striatal to hippocampal circuits.
Descripción : Este artículo se encuentra disponible en la siguiente URL: https://www.nature.com/articles/s41598-020-68025-y.pdf
En este artículo también participan: Alberto Oliverio y Andrea Mele.
URI : http://hdl.handle.net/10637/12713
Derechos: http://creativecommons.org/licenses/by/4.0/deed.es
ISSN : 2045-2322 (Electrónico).
Aparece en las colecciones: Dpto. Ciencias Biomédicas

Ficheros en este ítem:
Fichero Tamaño Formato  
Flexible_Rinaldi_SR_2020.pdf4,97 MBAdobe PDFVisualizar/Abrir

Los ítems de DSpace están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.