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dc.contributor.otherProducción Científica UCH 2020-
dc.contributor.otherUCH. Departamento de Ciencias Biomédicas-
dc.creatorRinaldi, Arianna-
dc.creatorDe Leonibus, Elvira-
dc.creatorCifra, Alessandra-
dc.creatorTorromino, Giulia-
dc.creatorMinicocci, Elisa-
dc.creatorDe Sanctis, Elisa-
dc.creatorLópez Pedrajas, Rosa María-
dc.date2020-
dc.date.accessioned2021-06-01T04:00:30Z-
dc.date.available2021-06-01T04:00:30Z-
dc.date.issued2020-07-09-
dc.identifier.citationRinaldi, A., De Leonibus, E., Cifra, A., Torromino, G., Minicocci, E., De Sanctis, E. et al. (2020). Flexible use of allocentric and egocentric spatial memories activates differential neural networks in mice. Scientific Reports, vol. 10, art. 11338 (09 jul.). DOI: https://doi.org/10.1038/s41598-020-68025-y-
dc.identifier.issn2045-2322 (Electrónico).-
dc.identifier.urihttp://hdl.handle.net/10637/12713-
dc.descriptionEste artículo se encuentra disponible en la siguiente URL: https://www.nature.com/articles/s41598-020-68025-y.pdf-
dc.descriptionEn este artículo también participan: Alberto Oliverio y Andrea Mele.-
dc.description.abstractGoal-directed navigation can be based on world-centered (allocentric) or body-centered (egocentric) representations of the environment, mediated by a wide network of interconnected brain regions, including hippocampus, striatum and prefrontal cortex. The relative contribution of these regions to navigation from novel or familiar routes, that demand a different degree of flexibility in the use of the stored spatial representations, has not been completely explored. To address this issue, we trained mice to find a reward relying on allocentric or egocentric information, in a modified version of the cross-maze task. Then we used Zif268 expression to map brain activation when well-trained mice were required to find the goal from a novel or familiar location. Successful navigation was correlated with the activation of CA1, posterior-dorsomedial striatum, nucleus accumbens core and infralimbic cortex when allocentric-trained mice needed to use a novel route. Allocentric navigation from a familiar route activated dorsomedial striatum, nucleus accumbens, prelimbic and infralimbic cortex. None of the structures analyzed was significantly activated in egocentric-trained mice, irrespective of the starting position. These data suggest that a flexible use of stored allocentric information, that allows goal finding even from a location never explored during training, induces a shift from fronto-striatal to hippocampal circuits.-
dc.formatapplication/pdf-
dc.language.isoen-
dc.language.isoes-
dc.publisherNature Research.-
dc.relation.ispartofScientific Reports, vol. 10.-
dc.rightshttp://creativecommons.org/licenses/by/4.0/deed.es-
dc.subjectMemory.-
dc.subjectRedes neuronales (Neurobiología)-
dc.subjectMemoria.-
dc.subjectNeurobiology.-
dc.subjectNeurobiología.-
dc.subjectNeural networks (Neurobiology)-
dc.titleFlexible use of allocentric and egocentric spatial memories activates differential neural networks in mices-
dc.typeArtículo-
dc.identifier.doihttps://doi.org/10.1038/s41598-020-68025-y-
dc.centroUniversidad Cardenal Herrera-CEU-
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