Por favor, use este identificador para citar o enlazar este ítem: http://hdl.handle.net/10637/12661
Título : Micelles of progesterone for topical eye administration : interspecies and intertissues differences in ex vivo ocular permeability
Autor : Alambiaga Caravaca, Adrián Miguel.
Calatayud Pascual, María Aracely.
Rodilla Alamá, Vicente.
Concheiro Nine, Ángel Joaquín.
López Castellano, Alicia Cristina.
Álvarez Lorenzo, Carmen.
Materias: Retinitis pigmentosa - Treatment.Permeabilidad.Permeability.Retinitis pigmentaria - Tratamiento.Eye - Diseases - Treatment.Progesterona - Uso terapéutico.Progesterone - Therapeutic use.Ojos - Enfermedades - Tratamiento.
Fecha de publicación : 26-jul-2020
Editorial : MDPI.
Citación : Alambiaga-Caravaca, A.M., Calatayud-Pascual, M.A., Rodilla, V., Concheiro, A., López-Castellano, A. & Alvarez-Lorenzo, C. (2020). Micelles of Progesterone for topical eye administration: interspecies and intertissues differences in ex vivo ocular permeability. Pharmaceutics, vol. 12, i. 8 (26 jul.), art. 702. DOI: https://doi.org/10.3390/pharmaceutics12080702
Resumen : Progesterone (PG) may provide protection to the retina during retinitis pigmentosa, but its topical ocular supply is hampered by PG poor aqueous solubility and low ocular bioavailability. The development of e cient topical ocular forms must face up to two relevant challenges: Protective barriers of the eyes and lack of validated ex vivo tests to predict drug permeability. The aims of this study were: (i) To design micelles using Pluronic F68 and Soluplus copolymers to overcome PG solubility and permeability; and (ii) to compare drug di usion through the cornea and sclera of three animal species (rabbit, porcine, and bovine) to investigate interspecies di erences. Micelles of Pluronic F68 (3–4 nm) and Soluplus (52–59 nm) increased PG solubility by one and two orders of magnitude, respectively and exhibited nearly a 100% encapsulation e ciency. Soluplus systems showed in situ gelling capability in contrast to the low viscosity Pluronic F68 micelles. The formulations successfully passed the hen’s egg-chorioallantoic membrane test (HET-CAM) test. PG penetration through rabbit cornea and sclera was faster than through porcine or bovine cornea, although the di erences were also formulation-dependent. Porcine tissues showed intermediate permeability between rabbit and bovine. Soluplus micelles allowed greater PG accumulation in cornea and sclera whereas Pluronic F68 promoted a faster penetration of lower PG doses.
Descripción : Este artículo se encuentra disponible en la siguiente URL: https://www.mdpi.com/1999-4923/12/8/702
URI : http://hdl.handle.net/10637/12661
Derechos: http://creativecommons.org/licenses/by/4.0/deed.es
ISSN : 1660-4601 (Electrónico).
Aparece en las colecciones: Dpto. Farmacia

Ficheros en este ítem:
Fichero Tamaño Formato  
Micelles_Alambiaga_PHARMACEUTICS_2020.pdf4,49 MBAdobe PDFVisualizar/Abrir



Los ítems de DSpace están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.