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Micelles of progesterone for topical eye administration : interspecies and intertissues differences in ex vivo ocular permeability

Título : Micelles of progesterone for topical eye administration : interspecies and intertissues differences in ex vivo ocular permeability
Autor : Alambiaga Caravaca, Adrián Miguel
Calatayud Pascual, María Aracely
Rodilla Alamá, Vicente
Concheiro Nine, Ángel Joaquín
López Castellano, Alicia Cristina
Álvarez Lorenzo, Carmen
Materias: Retinitis pigmentosa - Treatment.Permeabilidad.Permeability.Retinitis pigmentaria - Tratamiento.Eye - Diseases - Treatment.Progesterona - Uso terapéutico.Progesterone - Therapeutic use.Ojos - Enfermedades - Tratamiento.
Editorial : MDPI.
Citación : Alambiaga-Caravaca, A.M., Calatayud-Pascual, M.A., Rodilla, V., Concheiro, A., López-Castellano, A. & Alvarez-Lorenzo, C. (2020). Micelles of Progesterone for topical eye administration: interspecies and intertissues differences in ex vivo ocular permeability. Pharmaceutics, vol. 12, i. 8 (26 jul.), art. 702. DOI: https://doi.org/10.3390/pharmaceutics12080702
Resumen : Progesterone (PG) may provide protection to the retina during retinitis pigmentosa, but its topical ocular supply is hampered by PG poor aqueous solubility and low ocular bioavailability. The development of e cient topical ocular forms must face up to two relevant challenges: Protective barriers of the eyes and lack of validated ex vivo tests to predict drug permeability. The aims of this study were: (i) To design micelles using Pluronic F68 and Soluplus copolymers to overcome PG solubility and permeability; and (ii) to compare drug di usion through the cornea and sclera of three animal species (rabbit, porcine, and bovine) to investigate interspecies di erences. Micelles of Pluronic F68 (3–4 nm) and Soluplus (52–59 nm) increased PG solubility by one and two orders of magnitude, respectively and exhibited nearly a 100% encapsulation e ciency. Soluplus systems showed in situ gelling capability in contrast to the low viscosity Pluronic F68 micelles. The formulations successfully passed the hen’s egg-chorioallantoic membrane test (HET-CAM) test. PG penetration through rabbit cornea and sclera was faster than through porcine or bovine cornea, although the di erences were also formulation-dependent. Porcine tissues showed intermediate permeability between rabbit and bovine. Soluplus micelles allowed greater PG accumulation in cornea and sclera whereas Pluronic F68 promoted a faster penetration of lower PG doses.
Descripción : Este artículo se encuentra disponible en la siguiente URL: https://www.mdpi.com/1999-4923/12/8/702
URI : http://hdl.handle.net/10637/12661
Derechos: http://creativecommons.org/licenses/by/4.0/deed.es
ISSN : 1660-4601 (Electrónico).
Fecha de publicación : 26-jul-2020
Centro : Universidad Cardenal Herrera-CEU
Aparece en las colecciones: Dpto. Farmacia





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