Por favor, use este identificador para citar o enlazar este ítem: http://hdl.handle.net/10637/12658
Título : Dissecting the phenotypic and functional heterogeneity of mouse inflammatory osteoclasts by the expression of Cx3cr1
Autor : Madel, Maria-Bernadette.
Ibáñez Torres, Lidia.
Ciucci, Thomas.
Halper, Julia.
Rouleau, Matthieu.
Boutin, Antoine.
Materias: Sistema inmune.Immune system.T cells.Macrófagos.Macrophages.Células dendríticas.Bones - Immunology.Osteoclastos.Inmunorrespuesta.Immune response.Células T.Osteoclasts.Huesos - Inmunología.Dendritics cells.
Fecha de publicación : 13-may-2020
Editorial : eLife Sciences.
Citación : Madel, M.B., Ibáñez, L., Ciucci, T., Halper, J., Rouleau, M., Boutin, A. et al. (2020). Dissecting the phenotypic and functional heterogeneity of mouse inflammatory osteoclasts by the expression of Cx3cr1. eLife, vol. 9, art. e54493 (13 may.). DOI: https://doi.org/10.7554/eLife.54493
Resumen : Bone destruction relies on interactions between bone and immune cells. Bone- resorbing osteoclasts (OCLs) were recently identified as innate immune cells activating T cells toward tolerance or inflammation. Thus, pathological bone destruction not only relies on increased osteoclast differentiation, but also on the presence of inflammatory OCLs (i-OCLs), part of which express Cx3cr1. Here, we investigated the contribution of mouse Cx3cr1+ and Cx3cr1neg i-OCLs to bone loss. We showed that Cx3cr1+ and Cx3cr1neg i-OCLs differ considerably in transcriptional and functional aspects. Cx3cr1neg i-OCLs have a high ability to resorb bone and activate inflammatory CD4+ T cells. Although Cx3cr1+ i-OCLs are associated with inflammation, they resorb less and have in vitro an immune-suppressive effect on Cx3cr1neg i-OCLs, mediated by PD-L1. Our results provide new insights into i-OCL heterogeneity. They also reveal that different i-OCL subsets may interact to regulate inflammation. This contributes to a better understanding and prevention of inflammatory bone destruction.
Descripción : Este artículo se encuentra disponible en la siguiente URL: https://elifesciences.org/articles/54493#info
En este artículo también participan: Christophe Hue, Isabelle Duroux-Richard, Florence Apparailly, Henri-Jean Garchon, Abdelilah Wakkach, Claudine Blin-Wakkach.
URI : http://hdl.handle.net/10637/12658
Derechos: http://creativecommons.org/licenses/by/4.0/deed.es
ISSN : 2050-084X (Electrónico).
Aparece en las colecciones: Dpto. Farmacia

Ficheros en este ítem:
Fichero Descripción Tamaño Formato  
Dissecting_Madel_ELIFE_2020.pdf3,79 MBAdobe PDFVisualizar/Abrir



Los ítems de DSpace están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.