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dc.contributor.otherProducción Científica UCH 2020-
dc.contributor.otherUCH. Departamento de Farmacia-
dc.creatorMadel, Maria-Bernadette.-
dc.creatorIbáñez Torres, Lidia.-
dc.creatorCiucci, Thomas.-
dc.creatorHalper, Julia.-
dc.creatorRouleau, Matthieu.-
dc.creatorBoutin, Antoine.-
dc.identifier.citationMadel, M.B., Ibáñez, L., Ciucci, T., Halper, J., Rouleau, M., Boutin, A. et al. (2020). Dissecting the phenotypic and functional heterogeneity of mouse inflammatory osteoclasts by the expression of Cx3cr1. eLife, vol. 9, art. e54493 (13 may.). DOI: https://doi.org/10.7554/eLife.54493-
dc.identifier.issn2050-084X (Electrónico).-
dc.descriptionEste artículo se encuentra disponible en la siguiente URL: https://elifesciences.org/articles/54493#info-
dc.descriptionEn este artículo también participan: Christophe Hue, Isabelle Duroux-Richard, Florence Apparailly, Henri-Jean Garchon, Abdelilah Wakkach, Claudine Blin-Wakkach.-
dc.description.abstractBone destruction relies on interactions between bone and immune cells. Bone- resorbing osteoclasts (OCLs) were recently identified as innate immune cells activating T cells toward tolerance or inflammation. Thus, pathological bone destruction not only relies on increased osteoclast differentiation, but also on the presence of inflammatory OCLs (i-OCLs), part of which express Cx3cr1. Here, we investigated the contribution of mouse Cx3cr1+ and Cx3cr1neg i-OCLs to bone loss. We showed that Cx3cr1+ and Cx3cr1neg i-OCLs differ considerably in transcriptional and functional aspects. Cx3cr1neg i-OCLs have a high ability to resorb bone and activate inflammatory CD4+ T cells. Although Cx3cr1+ i-OCLs are associated with inflammation, they resorb less and have in vitro an immune-suppressive effect on Cx3cr1neg i-OCLs, mediated by PD-L1. Our results provide new insights into i-OCL heterogeneity. They also reveal that different i-OCL subsets may interact to regulate inflammation. This contributes to a better understanding and prevention of inflammatory bone destruction.-
dc.publishereLife Sciences.-
dc.relation.ispartofeLife, vol. 9.-
dc.subjectSistema inmune.-
dc.subjectImmune system.-
dc.subjectT cells.-
dc.subjectCélulas dendríticas.-
dc.subjectBones - Immunology.-
dc.subjectImmune response.-
dc.subjectCélulas T.-
dc.subjectHuesos - Inmunología.-
dc.subjectDendritics cells.-
dc.titleDissecting the phenotypic and functional heterogeneity of mouse inflammatory osteoclasts by the expression of Cx3cr1-
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