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Título : A multihost bacterial pathogen overcomes continuous population bottlenecks to adapt to new host species.
Autor : Bacigalupe, Rodrigo.
Tormo Más, María Ángeles.
Penadés Casanova, José Rafael.
Fitzgerald, J. Ross.
Materias: Estafilococos.Staphylococcus.Bacterias patógenas.Pathogenic bacteria.Microbiología médica.Medical microbiology.Advertising agencies.Bacterial genetic.Bacteriología médica.Medical bacteriology.Microorganismos patógenos.Pathogenic microorganisms.Genética bacteriana.
Fecha de publicación : 27-nov-2019
Editorial : American Association for the Advancement of Science.
Citación : Bacigalupe, R., Tormo-Mas, MA., Penadés, JR. & Fitzgerald, JR. (2019). A multihost bacterial pathogen overcomes continuous population bottlenecks to adapt to new host species. Science Advances, vol. 5, n. 11 (27 nov.). DOI: https://www.doi.org/10.1126/sciadv.aax0063
Resumen : While many bacterial pathogens are restricted to single host species, some have the capacity to undergo host switches, leading to the emergence of new clones that are a threat to human and animal health. However, the bacterial traits that underpin a multihost ecology are not well understood. Following transmission to a new host, bacterial populations are influenced by powerful forces such as genetic drift that reduce the fixation rate of beneficial mutations, limiting the capacity for host adaptation. Here, we implement a novel experimental model of bacterial host switching to investigate the ability of the multihost pathogen Staphylococcus aureusto adapt to new species under continuous population bottlenecks. We demonstrate that beneficial mutations accumulated during infection can overcome genetic drift and sweep through the population, leading to host adaptation. Our findings highlight the remarkable capacity of some bacteria to adapt to distinct host niches in the face of powerful antagonistic population forces.
Descripción : Este es el artículo que se ha publicado de forma definitiva en: https://advances.sciencemag.org/content/5/11/eaax0063/tab-pdf
URI : http://hdl.handle.net/10637/10897
Derechos: http://creativecommons.org/licenses/by/4.0/deed.es
ISSN : 2375-2548 (Electrónico).
Aparece en las colecciones: Dpto. Ciencias Biomédicas

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