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dc.contributor.otherUCH. Departamento de Ciencias Biomédicas-
dc.contributor.otherProducción Científica UCH 2019-
dc.creatorBacigalupe, Rodrigo-
dc.creatorTormo Más, María Ángeles-
dc.creatorPenadés Casanova, José Rafael-
dc.creatorFitzgerald, J. Ross-
dc.date2019-
dc.date.accessioned2020-06-30T04:00:30Z-
dc.date.available2020-06-30T04:00:30Z-
dc.date.issued2019-11-27-
dc.identifier.citationBacigalupe, R., Tormo-Mas, MA., Penadés, JR. & Fitzgerald, JR. (2019). A multihost bacterial pathogen overcomes continuous population bottlenecks to adapt to new host species. Science Advances, vol. 5, n. 11 (27 nov.). DOI: https://www.doi.org/10.1126/sciadv.aax0063-
dc.identifier.issn2375-2548 (Electrónico).-
dc.identifier.urihttp://hdl.handle.net/10637/10897-
dc.descriptionEste es el artículo que se ha publicado de forma definitiva en: https://advances.sciencemag.org/content/5/11/eaax0063/tab-pdf-
dc.description.abstractWhile many bacterial pathogens are restricted to single host species, some have the capacity to undergo host switches, leading to the emergence of new clones that are a threat to human and animal health. However, the bacterial traits that underpin a multihost ecology are not well understood. Following transmission to a new host, bacterial populations are influenced by powerful forces such as genetic drift that reduce the fixation rate of beneficial mutations, limiting the capacity for host adaptation. Here, we implement a novel experimental model of bacterial host switching to investigate the ability of the multihost pathogen Staphylococcus aureusto adapt to new species under continuous population bottlenecks. We demonstrate that beneficial mutations accumulated during infection can overcome genetic drift and sweep through the population, leading to host adaptation. Our findings highlight the remarkable capacity of some bacteria to adapt to distinct host niches in the face of powerful antagonistic population forces.-
dc.formatapplication/pdf-
dc.language.isoen-
dc.language.isoes-
dc.publisherAmerican Association for the Advancement of Science.-
dc.relationEste artículo ha sido financiado por el Biotechnology and Biological Sciences Research Council (United Kingdom) (BB/K00638X/1 y BB/P013740/1), por el Medical Research Council (United Kingdom) (MR/N02995X/1), por un premio Wellcome Trust (201531/Z/16/Z), por el Medical Research Council (United Kingdom) (MR/M003876/1 y MR/S00940X/1), por el Biotechnology and Biological Sciences Research Council (BBSRC; United Kingdom) (N002873/1 y BB/S003835/1), por una ayuda de la Unión Europea (ERC-ADG-2014 proposal no. 670932) y unas ayudas concedidas por el Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria de España (RTA2011-00139-00-00 y SAF2017-82251-R) y por el Ministerio de Ciencia, Innovación y Universidades de España (CSD2009-00006).-
dc.relation.ispartofScience Advances, vol. 5, n. 11.-
dc.rightshttp://creativecommons.org/licenses/by/4.0/deed.es-
dc.subjectEstafilococos.-
dc.subjectStaphylococcus.-
dc.subjectBacterias patógenas.-
dc.subjectPathogenic bacteria.-
dc.subjectMicrobiología médica.-
dc.subjectMedical microbiology.-
dc.subjectAdvertising agencies.-
dc.subjectBacterial genetic.-
dc.subjectBacteriología médica.-
dc.subjectMedical bacteriology.-
dc.subjectMicroorganismos patógenos.-
dc.subjectPathogenic microorganisms.-
dc.subjectGenética bacteriana.-
dc.titleA multihost bacterial pathogen overcomes continuous population bottlenecks to adapt to new host species.-
dc.typeArtículo-
dc.identifier.doihttps://www.doi.org/10.1126/sciadv.aax0063-
dc.relation.projectIDRTA2011-00139-00-00-
dc.relation.projectIDSAF2017-82251-R-
dc.relation.projectIDCSD2009-00006-
dc.centroUniversidad Cardenal Herrera-CEU-
Aparece en las colecciones: Dpto. Ciencias Biomédicas




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