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http://hdl.handle.net/10637/10614Salivary biomarkers and their efficacies as diagnostic tools for Oral Squamous Cell Carcinoma : systematic review and meta-analysis
| Title: | Salivary biomarkers and their efficacies as diagnostic tools for Oral Squamous Cell Carcinoma : systematic review and meta-analysis |
| Authors : | Gaba, Fariah Sheth Shah, Chirag Chandrakant. Veses Jiménez, Verónica. |
| Keywords: | Saliva - Análisis.; Marcadores tumorales.; Cancer cells.; Células cancerosas.; Saliva - Analysis.; Boca - Cáncer.; Mouth - Cancer.; Tumor markers. |
| Publisher: | John Wiley & Sons. |
| Citation: | Gaba, FI., Sheth, CC. & Veses, V. (2021). Salivary biomarkers and their efficacies as diagnostic tools for Oral Squamous Cell Carcinoma : systematic review and meta-analysis. Journal of Oral Pathology and Medicine, vol. 50, i. 3 (mar.), pp. 299-307. DOI: https://doi.org/10.1111/jop.12791 |
| Abstract: | More than 90% of malignant tumors of the head and neck are oral squamous cell carcinomas (OSCC). Early OSCC detection using salivary biomarkers could prevent malignant transformations and enhance patient survival. A systematic search in MEDLINE and the Central Register of Controlled Trials and meta-analysis were undertaken to identify the screening potential of 6 salivary biomarkers for early OSCC detection: IL-8, IL1-β, DUSP-1 and S100P mRNAs, miR125a and miR200a microRNAs. The sensitivities of IL-8 (0.41; 95%CI 0.19-0.99), IL1-β (0.26; 95%CI 0.19- 0.99), DUSP-1 (0.61; 95%CI 0.01-0.98), and S100P (0.67; 95%CI 0.32- 0.99) were calculated. Specificities of the biomarkers analyzed were found to be IL-8 (0.69; 95%CI 0.66-0.99), IL1-β (0.47; 95%CI 0.46 - 0.90), DUSP-1 (0.75; 95%CI 0.33-1) and S100P (0.73; 95%CI 0.18-0.99). Early detection of OSCC was best achieved by screening for salivary mRNA DUSP-1 and S100P. Further investigation is required into miRNAs as novel biomarkers |
| Description: | Esta es la versión pre-print del artículo, el cual se encuentra disponible en la siguiente URL: https://onlinelibrary.wiley.com/doi/full/10.1111/jop.12791 |
| URI: | http://hdl.handle.net/10637/10614 |
| Rights : | http://creativecommons.org/licenses/by-nc-nd/4.0/deed.es |
| ISSN: | 0904-2512 1600-0714 (Electrónico) |
| Issue Date: | 19-Mar-2021 |
| Center : | Universidad Cardenal Herrera-CEU |
| Appears in Collections: | Dpto. Ciencias Biomédicas |
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