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Título : Salivary biomarkers and their efficacies as diagnostic tools for Oral Squamous Cell Carcinoma : systematic review and meta-analysis / Fariah I. Gaba, Chirag C. Sheth and Veronica Veses.
Autor : Gaba, Fariah.
Sheth Shah, Chirag Chandrakant.
Veses Jiménez, Verónica.
Materias: Saliva - Análisis.Marcadores tumorales.Cancer cells.Células cancerosas.Saliva - Analysis.Boca - Cáncer.Mouth - Cancer.Tumor markers.
Fecha de publicación : 19-oct-2018
Editorial : John Wiley & Sons.
Citación : Gaba, FI., Sheth, CC. & Veses, V. (2018). Salivary biomarkers and their efficacies as diagnostic tools for Oral Squamous Cell Carcinoma : systematic review and meta-analysis. Journal of Oral Pathology and Medicine, (19 oct. 2018). DOI: https://doi.org/10.1111/jop.12791
Resumen : More than 90% of malignant tumors of the head and neck are oral squamous cell carcinomas (OSCC). Early OSCC detection using salivary biomarkers could prevent malignant transformations and enhance patient survival. A systematic search in MEDLINE and the Central Register of Controlled Trials and meta-analysis were undertaken to identify the screening potential of 6 salivary biomarkers for early OSCC detection: IL-8, IL1-β, DUSP-1 and S100P mRNAs, miR125a and miR200a microRNAs. The sensitivities of IL-8 (0.41; 95%CI 0.19-0.99), IL1-β (0.26; 95%CI 0.19- 0.99), DUSP-1 (0.61; 95%CI 0.01-0.98), and S100P (0.67; 95%CI 0.32- 0.99) were calculated. Specificities of the biomarkers analyzed were found to be IL-8 (0.69; 95%CI 0.66-0.99), IL1-β (0.47; 95%CI 0.46 - 0.90), DUSP-1 (0.75; 95%CI 0.33-1) and S100P (0.73; 95%CI 0.18-0.99). Early detection of OSCC was best achieved by screening for salivary mRNA DUSP-1 and S100P. Further investigation is required into miRNAs as novel biomarkers
Descripción : Esta es la versión pre-print del artículo, el cual se encuentra disponible en la siguiente URL: https://onlinelibrary.wiley.com/doi/full/10.1111/jop.12791
URI : http://hdl.handle.net/10637/10614
Derechos: http://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
ISSN : 0904-2512
1600-0714 (Electrónico)
Aparece en las colecciones: Dpto. Ciencias Biomédicas

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