Por favor, use este identificador para citar o enlazar este ítem: http://hdl.handle.net/10637/1024
Título : Development of a frit-free SPE-based in-column prconcentration system for capillary electrophoresis.
Autor : Saavedra, L.
Maeso, M.
Cifuentes, Alejandro.
Barbas Arribas, Coral.
Materias: Solid phase extractionSample preconcentrationCleanupSmall moleculesCapillary electrophoresis
Fecha de publicación : 19-sep-2007
Resumen : An in-capillary sample preconcentration strategy based on solid phase extraction (SPE) technology coupled with capillary electrophoresis (CE) has been developed taking advantage of both techniques (SPE and CE). An in-line frit-free preconcentration device for capillary electrophoresis containing MCX beads, obtained from the corresponding Waters OASIS® cartridges, was prepared. The retention of the particles was based on the relative diameters of the particles, carefully selected, and the capillaries. An experimental preconcentration factor of 100 was found for the system. Conditions were optimised for 3-nitrotyrosine measurement in rat urine being 4.4 M spiked in the urine the lowest value detectable.

An in-capillary sample preconcentration strategy based on solid phase extraction (SPE) technology coupled with capillary electrophoresis (CE) has been developed taking advantage of both techniques (SPE and CE). An in-line frit-free preconcentration device for capillary electrophoresis containing MCX beads, obtained from the corresponding Waters OASIS® cartridges, was prepared. The retention of the particles was based on the relative diameters of the particles, carefully selected, and the capillaries. An experimental preconcentration factor of 100 was found for the system. Conditions were optimised for 3-nitrotyrosine measurement in rat urine being 4.4 M spiked in the urine the lowest value detectable.
Descripción : En: Journal of pharmaceutical and biomedical analysis. ISSN. 0731-7085. v. 44, 2 (2007), p. 471-476
URI : http://hdl.handle.net/10637/1024
Derechos: http://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
Otros identificadores : 000000450129
Aparece en las colecciones: Facultad de Farmacia

Ficheros en este ítem:
Fichero Descripción Tamaño Formato  
Development_Saavedra_et_J_Pharm&Bio_Anal_2007.pdf533,63 kBAdobe PDFVisualizar/Abrir



Los ítems de DSpace están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.