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dc.contributor.otherProducción Científica UCH 2018-
dc.contributor.otherUCH. Departamento de Ciencias Biomédicas-
dc.contributor.otherUCH. Departamento de Farmacia-
dc.creatorTrachsel Moncho, Laura.es
dc.creatorBenlloch Navarro, María Soledad.es
dc.creatorFernández Carbonell, Ángel.es
dc.creatorRamírez Lamelas, Dolores Tania.es
dc.creatorOlivar Rivas, Teresa.es
dc.creatorSilvestre Castelló, María Dolores.es
dc.creatorPoch Jiménez, Enric.es
dc.creatorMiranda Sanz, María.es
dc.date2018es
dc.date.accessioned2019-04-10T04:00:21Z-
dc.date.available2019-04-10T04:00:21Z-
dc.date.issued2018-04-10-
dc.identifier.citationTrachsel Moncho, L., Benlloch Navarro, S., Fernández Carbonell, Á., Ramírez Lamelas, DT., Olivar, T., Silvestre, D. et al. (2018). Oxidative stress and autophagy-related changes during retinal degeneration and development. Cell Death & Disease, vol. 9, art. 812. DOI: https://doi.org/10.1038/s41419-018-0855-8-
dc.identifier.issn2041-4889.-
dc.identifier.urihttp://hdl.handle.net/10637/10156-
dc.descriptionEste artículo se encuentra disponible en la página web de la revista en la siguiente URL: https://www.nature.com/articles/s41419-018-0855-8es
dc.description.abstractRetinitis pigmentosa (RP) is an inherited retinopathy that leads to photoreceptor loss. RP has been related to oxidative stress, autophagy, and inflammation. This study aimed to identify changes in the levels of oxidative stress and autophagy markers in the retina of control and rd10 mice during different phases of retinal development. Changes in the retinal oxidation system were investigated by measuring the levels of oxidized and reduced glutathione (GSH/GSSG), retinal avidin-positive cells, and 4-hydroxynonenal (4-HNE) staining intensity. Autophagy characterization was explored by measuring the levels of microtubule-associated protein 1 light chain 3 (LC3), beclin, autophagy-related proteins 5 and 7 (Atg5 and Atg7), and lysosomal associated membrane protein-2A (LAMP-2A). At P28 retinal GSH concentrations decreased in rd10 mice compared to the controls. No differences were found in retinal GSSG concentrations between the control and rd10 mice. There was an increase in retinal GSSG concentrations and a decrease in the GSH/GSSG ratio in the control and rd10 mice at P21 and P28 compared to P13. We observed an increase in avidin-positive cells in rd10 retinas. 4-HNE was increased in rd10 retinas at P13, and it also increased in control mice with age. We did not observe any differences in the retinal levels of LC3II/I ratio, Beclin, Atg5, or Atg7 in the rd10 mice compared to the controls. There was an increase in the LAMP-2A concentrations in the control and rd10 mice with development age (P28 concentrations vs. P13). Although only slight differences were found in the oxidative stress and autophagy markers between the control and rd10 mice, there were increases in the GSSG, 4-HNE, and LAMP-2A with age. This increase in the oxidative stress and chaperone-mediated autophagy has not been described before and occurred just after the mice opened their eyes, potentially indicating a retinal response to light exposure.-
dc.formatapplication/pdfes
dc.language.isoenes
dc.publisherSpringer Nature Publishing AG.-
dc.relationEste artículo ha sido financiado por la Universidad CEU Cardenal Herrera y por la Fundación Universitaria San Pablo CEU (FUSPBS-PPC 33/201 y Consolidación 2017/18).-
dc.relationFinanciación Universidad.-
dc.relation.ispartofCell Death & Disease, vol. 9 (2018)-
dc.rightshttp://creativecommons.org/licenses/by/4.0/deed.eses
dc.subjectRetina - Enfermedades.es
dc.subjectEnfermedades genéticas.es
dc.subjectGenetic disorders.es
dc.subjectRetina - Diseases.es
dc.subjectRetinosis pigmentaria.es
dc.subjectEstrés oxidativo.es
dc.subjectOxidative stress.es
dc.subjectRetinitis pigmentosa.es
dc.titleOxidative stress and autophagy-related changes during retinal degeneration and development / Laura Trachsel-Moncho, Soledad Benlloch-Navarro, Ángel Fernández-Carbonell, Dolores Tania Ramírez-Lamelas, Teresa Olivar, Dolores Silvestre, Enric Poch & María Miranda.es
dc.typeArtículoes
europeana.dataProviderUNIVERSIDAD SAN PABLO CEU-
europeana.isShownAthttp://hdl.handle.net/10637/10156-
europeana.objecthttp://repositorioinstitucional.ceu.es/visor/libros/708948/thumb_europeana/708948.jpg-
europeana.providerUNIVERSIDAD SAN PABLO CEU-
europeana.rightshttp://creativecommons.org/publicdomain/zero/1.0/-
europeana.typeTEXT-
dc.identifier.doihttps://doi.org/10.1038/s41419-018-0855-8-
dc.relation.projectIDFUSPBS-PPC 33/201-
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