Por favor, use este identificador para citar o enlazar este ítem: http://hdl.handle.net/10637/10061
Título : A pharmacological update of ellagic acid / José Luis Ríos, Rosa M. Giner, Marta Marín and M. Carmen Recio.
Autor : Ríos Cañavate, José Luis.
Giner Pons, Rosa María.
Marín Vázquez, Marta.
Recio Iglesias, María Carmen.
Palabras clave : Ellagic acid - Pharmacokinetics.
Ácido elágico - Efectos fisiológicos.
Ellagic acid - Physiological effect.
Antioxidantes.
Metabolismo - Trastornos.
Proteína quinasa.
Metabolism - Disorders.
Protein kinases.
Ácido elágico - Farmacocinética.
Antioxidants.
Fecha de publicación : 5-mar-2019
Citación : Ríos, JL., Giner, RM., Marín, M. and Recio, MC. (2018). A pharmacological update of ellagic acid. Planta Medica, vol. 84, n. 15, pp. 1068-1093. DOI: https://doi.org/10.1055/a-0633-9492
Resumen : Ellagic acid is a common metabolite present in many medicinal plants and vegetables. It is present either in free form or as part of more complex molecules (ellagitannins), which can be metabolized to liberate ellagic acid and several of its metabolites, including urolithins. While ellagic acidʼs antioxidant properties are doubtless responsible for many of its pharmacological activities, other mechanisms have also been implicated in its various effects, including its ability to reduce the lipidemic profile and lipid metabolism, alter pro-inflammatory mediators (tumor necrosis factor-α, interleukin-1β, interleukin-6), and decrease the activity of nuclear factor-κB while increasing nuclear factor erythroid 2-related factor 2 expression. These events play an important role in ellagic acidʼs anti-atherogenic, anti-inflammatory, and neuroprotective effects. Several of these activities, together with the effect of ellagic acid on insulin, glycogen, phosphatases, aldose reductase, sorbitol accumulation, advanced glycation end-product formation, and resistin secretion, may explain its effects on metabolic syndrome and diabetes. In addition, results from recent research have increased the interest in ellagic acid, both as a potential protective agent of the liver and skin and as a potential anticancer agent, due to the specific mechanisms affecting cell proliferation, apoptosis, DNA damage, and angiogenesis and its aforementioned anti-inflammatory properties. Taken together, these effects make ellagic acid a highly interesting compound that may contribute to different aspects of health; however, more studies are needed, especially on the compoundʼs pharmacokinetic profile. In this review, we selected papers published from 2005 to the present.
Descripción : En Planta Medica. Stuttgart (Germany) : Georg Thieme Verlag KG. Vol. 84 (october 2018), n. 15, pp. 1068-1093.
Este artículo se encuentra disponible en la página web de la revista en la siguiente URL: https://www.thieme-connect.com/products/ejournals/pdf/10.1055/a-0633-9492.pdf
This is a pre-print of an article published in Ríos, JL., Giner, RM., Marín, M. and Recio, MC. (2018). A pharmacological update of ellagic acid. Planta Medica, vol. 84, n. 15, pp. 1068-1093. The final authenticated version is available online at: https://doi.org/10.1055/a-0633-9492
Este es el pre-print del siguiente artículo Ríos, JL., Giner, RM., Marín, M. and Recio, MC. (2018). A pharmacological update of ellagic acid. Planta Medica, vol. 84, n. 15, pp. 1068-1093 que se ha publicado de forma definitiva en https://doi.org/10.1055/a-0633-9492
URI : http://hdl.handle.net/10637/10061
ISSN : 0032-0943.
Aparece en las colecciones: Farmacia

Ficheros en este ítem:
Fichero Tamaño Formato  
A pharmacological update of ellagic acid - Preprint.pdf28,34 MBAdobe PDFVisualizar/Abrir



Los ítems de DSpace están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.