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dc.contributor.otherProducción Científica UCH 2018-
dc.contributor.otherUCH. Departamento de Farmacia-
dc.creatorRíos Cañavate, José Luises
dc.creatorGiner Pons, Rosa Maríaes
dc.creatorMarín Vázquez, Martaes
dc.creatorRecio Iglesias, María Carmenes
dc.date2018es
dc.date.accessioned2019-03-05T05:00:29Z-
dc.date.available2019-03-05T05:00:29Z-
dc.date.issued2018-10-05-
dc.identifier.citationRíos, JL., Giner, RM., Marín, M. and Recio, MC. (2018). A pharmacological update of ellagic acid. Planta Medica, vol. 84, n. 15, pp. 1068-1093. DOI: https://doi.org/10.1055/a-0633-9492-
dc.identifier.issn0032-0943.-
dc.identifier.urihttp://hdl.handle.net/10637/10061-
dc.descriptionEste artículo se encuentra disponible en la página web de la revista en la siguiente URL: https://www.thieme-connect.com/products/ejournals/pdf/10.1055/a-0633-9492.pdfes
dc.descriptionThis is a pre-print of an article published in Ríos, JL., Giner, RM., Marín, M. and Recio, MC. (2018). A pharmacological update of ellagic acid. Planta Medica, vol. 84, n. 15, pp. 1068-1093. The final authenticated version is available online at: https://doi.org/10.1055/a-0633-9492-
dc.descriptionEste es el pre-print del siguiente artículo Ríos, JL., Giner, RM., Marín, M. and Recio, MC. (2018). A pharmacological update of ellagic acid. Planta Medica, vol. 84, n. 15, pp. 1068-1093 que se ha publicado de forma definitiva en https://doi.org/10.1055/a-0633-9492-
dc.description.abstractEllagic acid is a common metabolite present in many medicinal plants and vegetables. It is present either in free form or as part of more complex molecules (ellagitannins), which can be metabolized to liberate ellagic acid and several of its metabolites, including urolithins. While ellagic acidʼs antioxidant properties are doubtless responsible for many of its pharmacological activities, other mechanisms have also been implicated in its various effects, including its ability to reduce the lipidemic profile and lipid metabolism, alter pro-inflammatory mediators (tumor necrosis factor-α, interleukin-1β, interleukin-6), and decrease the activity of nuclear factor-κB while increasing nuclear factor erythroid 2-related factor 2 expression. These events play an important role in ellagic acidʼs anti-atherogenic, anti-inflammatory, and neuroprotective effects. Several of these activities, together with the effect of ellagic acid on insulin, glycogen, phosphatases, aldose reductase, sorbitol accumulation, advanced glycation end-product formation, and resistin secretion, may explain its effects on metabolic syndrome and diabetes. In addition, results from recent research have increased the interest in ellagic acid, both as a potential protective agent of the liver and skin and as a potential anticancer agent, due to the specific mechanisms affecting cell proliferation, apoptosis, DNA damage, and angiogenesis and its aforementioned anti-inflammatory properties. Taken together, these effects make ellagic acid a highly interesting compound that may contribute to different aspects of health; however, more studies are needed, especially on the compoundʼs pharmacokinetic profile. In this review, we selected papers published from 2005 to the present.-
dc.formatapplication/pdfes
dc.language.isoenes
dc.publisherGeorg Thieme Verlag KG-
dc.relation.ispartofPlanta Medica, vol. 84 (october 2018), n. 15-
dc.rightshttp://creativecommons.org/licenses/by-nc-nd/4.0/deed.eses
dc.subjectEllagic acid - Pharmacokinetics.es
dc.subjectÁcido elágico - Efectos fisiológicos.es
dc.subjectEllagic acid - Physiological effect.es
dc.subjectAntioxidantes.es
dc.subjectMetabolismo - Trastornos.es
dc.subjectProteína quinasa.es
dc.subjectMetabolism - Disorders.es
dc.subjectProtein kinases.es
dc.subjectÁcido elágico - Farmacocinética.es
dc.subjectAntioxidants.es
dc.titleA pharmacological update of ellagic acides
dc.typeArtículoes
europeana.dataProviderUNIVERSIDAD SAN PABLO CEU-
europeana.isShownAthttp://hdl.handle.net/10637/10061-
europeana.objecthttp://repositorioinstitucional.ceu.es/visor/libros/707854/thumb_europeana/707854.jpg-
europeana.providerHispana-
europeana.rightshttp://creativecommons.org/publicdomain/zero/1.0/-
europeana.typeTEXT-
dc.identifier.doihttps://doi.org/10.1055/a-0633-9492-
dc.centroUniversidad Cardenal Herrera-CEU-
Aparece en las colecciones: Dpto. Farmacia




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