Brain Metastasis Response to Stereotactic Radio Surgery: A Mathematical Approach

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dc.centroUniversidad San Pablo-CEU
dc.contributor.authorLeón-Triana, Odelaisy
dc.contributor.authorPérez-Beteta, Julián
dc.contributor.authorAlbillo, David
dc.contributor.authorPérez-Romasanta, Luis
dc.contributor.authorGonzález-Del Portillo, Elisabet
dc.contributor.authorLlorente, Manuel
dc.contributor.authorCarballo, Natalia
dc.contributor.authorArana, Estanislao
dc.contributor.authorPérez-García, Víctor M.
dc.contributor.authorOrtiz de Mendivil Arrate, Ana
dc.contributor.otherGrupo: Spanish Back Pain Research Network (REIDE)
dc.date.accessioned2024-02-08T14:40:37Z
dc.date.available2024-02-08T14:40:37Z
dc.date.issued2021-03-26
dc.description.abstractBrain metastases (BMs) are cancer cells that spread to the brain from primary tumors in other organs. Up to 35% of adult cancer patients develop BMs. The treatment of BM patients who have well-controlled extracranial disease and a small number of lesions consists of localized doses of radiation (stereotactic radio surgery (SRS)). Estimating prognosis among BM patients may allow treatments to be chosen that balance durability of intracranial tumor control with quality of life and the side effects of treatment. No mathematical model-based quantitative biomarkers have been determined for estimating prognosis. As a first step toward that goal, we describe a mathematical model of growth and response of brain metastasis to stereotactic radio surgery. The mathematical model incorporates some biological mechanisms involved in BM growth and response to SRS and allows the observed dynamics to be accurately described.es_ES
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dc.identifier.citationLeón-Triana, O.; Pérez-Beteta , J.; Albillo, D.; Ortiz de Mendivil, A.; Pérez-Romasanta, L.; González-Del Portillo, E.; Llorente, M.; Carballo, N.; Arana, E.; Pérez-García, V.M. Brain Metastasis Response to Stereotactic Radio Surgery: A Mathematical Approach. Mathematics 2021, 9, 716. https://doi.org/10.3390/math9070716es_ES
dc.identifier.doi10.3390/math9070716
dc.identifier.urihttp://hdl.handle.net/10637/15398
dc.language.isoenes_ES
dc.publisherMDPIes_ES
dc.relation.ispartofMathematics
dc.relation.projectIDSupported by Ministerio de Ciencia e Innovación, Spain (grant number PID2019-110895RB-I00), and Junta de Comunidades de Castilla-La Mancha (grant number SBPLY/ 17/180501/000154). OLT is supported by a PhD Fellowship from the University of Castilla-La Mancha research plan.
dc.rightsopen access
dc.rights.cchttps://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subjectBrain metastasises_ES
dc.subjectMathematical modelinges_ES
dc.subjectMathematical oncologyes_ES
dc.subjectOrdinary differential equationes_ES
dc.subjectStereotactic radio surgeryes_ES
dc.titleBrain Metastasis Response to Stereotactic Radio Surgery: A Mathematical Approaches_ES
dc.typeArtículoes_ES
dspace.entity.typePublicationes
relation.isAuthorOfPublication128d29d8-a05b-456f-afa1-1bf8de84617e
relation.isAuthorOfPublication.latestForDiscovery128d29d8-a05b-456f-afa1-1bf8de84617e

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