Stereo- and regioselectivity in the P450-catalyzed oxidative tandem difunctionalization of 1-methylcyclohexene

Simple item page
dc.centroUniversidad San Pablo-CEU
dc.contributor.authorRoiban, Gheorghe-Doru
dc.contributor.authorReetz, Manfred T.
dc.contributor.authorAgudo Torres, Rubén
dc.contributor.otherUniversidad San Pablo-CEU. Departamento de Ciencias Farmacéuticas y de la Salud
dc.contributor.otherGrupo: Parasitología e Inmunología molecular con aplicación biotecnológica, diagnóstica y terapéutica (PARINM)
dc.date.accessioned2024-04-10T15:26:46Z
dc.date.available2024-04-10T15:26:46Z
dc.date.issued2013-05-06
dc.descriptionAcceso al contenido del artículo en la siguiente URL: https://doi.org/10.1016/j.tet.2013.04.132es_ES
dc.description.abstractThe selective partial oxidation of small non-functionalized molecules using biocatalysis based on P450 monooxygenases is known to be difficult due to the expected poor regio- and stereoselectivity, but in this study it was nevertheless attempted. 1-Methylcyclohexene was subjected to oxygen-mediated bio catalytic oxidation using P450-BM3 as the catalyst. Both oxidative hydroxylation and epoxidation were observed, in some cases leading to hydroxy epoxides with high diastereo- and enantioselectivity espe cially when employing BM3 mutants.en_EN
dc.identifier.citationGheorghe-Doru Roiban, Rubén Agudo, Manfred T. Reetz, Stereo- and regioselectivity in the P450-catalyzed oxidative tandem difunctionalization of 1-methylcyclohexene, Tetrahedron, Volume 69, Issue 26, 2013, Pages 5306-5311, ISSN 0040-4020, https://doi.org/10.1016/j.tet.2013.04.132.en_EN
dc.identifier.doi10.1016/j.tet.2013.04.132
dc.identifier.issn0040-4020
dc.identifier.urihttp://hdl.handle.net/10637/15722
dc.language.isoen
dc.publisherElsevier
dc.relation.ispartofTetrahedron
dc.rightsopen access
dc.rights.cchttps://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subjectEnantioselectivityen_EN
dc.subjectCH-activationen_EN
dc.subjectP450en_EN
dc.subjectMonooxygenaseen_EN
dc.subjectDiastereoselectivityen_EN
dc.titleStereo- and regioselectivity in the P450-catalyzed oxidative tandem difunctionalization of 1-methylcyclohexeneen_EN
dc.typeArtículo
dspace.entity.typePublicationes
relation.isAuthorOfPublication6c8d28e1-0f33-443a-a16b-508aef52ff02
relation.isAuthorOfPublication.latestForDiscovery6c8d28e1-0f33-443a-a16b-508aef52ff02

Files

Original bundle

Now showing 1 - 2 of 2
Thumbnail Image
Name:
Stereo_Rooban_Agudo_Reetz_Tetra_2013.PNG
Size:
8.24 KB
Format:
Portable Network Graphics
Description:
Download
Thumbnail Image
Name:
Stereo_Rooban_Agudo_Reetz_Tetra_2013.pdf
Size:
726.58 KB
Format:
Adobe Portable Document Format
Description:
Download

Collections

Facultad de Farmacia
x

The user has the obligation to use the services and content provided by the University, in particular, printed and electronic resources, in accordance with current legislation and the principles of good faith and generally accepted uses, without contravening with its performance the public order, especially, in the case in which, for the adequate performance of its activity, it needs to reproduce, distribute, communicate and/or make available, fragments of printed works or capable of being in analog or digital format, either on paper or electronic support. Law 23/2006, of July 7, which modifies the revised text of the Intellectual Property Law, approved by Royal Legislative Decree 1/1996, of April 12. B.O.E. n 162, of July 8, and concordant regulations.

@ 2024 Fundación Universitaria San Pablo CEU (Madrid). All rights reserved.

DSpace Software Copyright © 2002-2013 Duraspace