Cocaine and amphetamine regulated transcript and brain-derived neurotrophic factor in morbid obesity. One-year follow-up after gastric bypass

dc.centroUniversidad San Pablo-CEU
dc.contributor.authorMuñoz Rodríguez, José Ramón
dc.contributor.authorAlguacil Merino, Luis Fernando
dc.contributor.authorAgarrado, Andrea
dc.contributor.authorMartín Fernández, Jesús
dc.contributor.authorSalas, Elisabet
dc.contributor.authorGonzález Martín, Carmen
dc.contributor.otherGrupo: Neurofarmacología de las adicciones y los trastornos degenerativos (NEUROFAN)
dc.date.accessioned2024-02-06T12:36:24Z
dc.date.available2024-02-06T12:36:24Z
dc.date.issued2018-11
dc.descriptionEste artículo es la versión aceptada siguiendo la política de la revista
dc.description.abstractBackground: The outcomes of bariatric surgery are very irregular and mostly unpredictable. The search for variables of predictive value is encouraged to help preventing therapeutic failures. Objective: We aimed to confirm the hypothesis that preexisting eating behaviors could predict neuroendocrine and metabolic outcomes of gastric bypass surgery in morbidly obese subjects. Methods: Twenty-one morbidly obese patients from the Bariatric Surgery Program of our hospital were selected according to the specific inclusion and exclusion criteria for this study. The subjects filled out a validated questionnaire to quantify the "loss-of-control" (LC) dimension of food craving and provided serum samples at the onset of the study and 1 year after gastric bypass surgery. Hematological, metabolic, and hormonal variables were studied by conventional clinical tests and enzyme immunoassays and checked for correlations with LC both before and after surgery. Results: Those patients that had exhibited worse eating control at the beginning of the study experienced a better metabolic response 1 year after surgery in terms of reduction of serum insulin, HOMA1-IR, HOMA2-IR, and vitamin D1; all these variables were inversely correlated with presurgical LC. Serum brain-derived neurotrophic factor (BDNF) levels showed the same tendency; in fact, BDNF significantly decreased only in those patients with worse eating control. Conclusions: Problematic eating behaviors may predict a better response of insulin resistance and a specific reduction of serum BDNF in morbidly obese patients after gastric bypass surgery.es_ES
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dc.identifier.citationMuñoz-Rodríguez JR, Agarrado A, Martín-Fernández J, Salas E, González-Martín C, Alguacil LF. Cocaine and amphetamine regulated transcript and brain-derived neurotrophic factor in morbid obesity. One-year follow-up after gastric bypass. Surg Obes Relat Dis. 2018 Nov;14(11):1732-1739. doi: 10.1016/j.soard.2018.07.026.es_ES
dc.identifier.doi10.1016/j.soard.2018.07.026
dc.identifier.issn1550-7289
dc.identifier.urihttp://hdl.handle.net/10637/15364
dc.language.isoen
dc.publisherElsevieren_EN
dc.relation.ispartofSurgery for Obesity and Related Diseases
dc.rightsopen access
dc.rights.cchttps://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subjectBDNFen_EN
dc.subjectCARTen_EN
dc.subjectMorbid obesityen_EN
dc.subjectObesity biomarkersen_EN
dc.subjectRoux-en-y gastric bypassen_EN
dc.titleCocaine and amphetamine regulated transcript and brain-derived neurotrophic factor in morbid obesity. One-year follow-up after gastric bypassen_EN
dc.typeArtículoen_EN
dspace.entity.typePublicationes
relation.isAuthorOfPublication2747a8d9-6ffb-40e6-a549-42f55ccd2712
relation.isAuthorOfPublicatione10861fe-ea9b-4ccd-91c4-9cabc15a48d7
relation.isAuthorOfPublication.latestForDiscovery2747a8d9-6ffb-40e6-a549-42f55ccd2712

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