Streptozotocin-induced diabetes decreases mammary gland lipoprotein lipase activity and messenger ribonucleic acid in pregnant and nonpregnant rats.

Simple item page
dc.centroUniversidad San Pablo-CEU
dc.contributor.authorBlanco-Dolado, Laura-
dc.contributor.authorMartín Hidalgo, Antonia-
dc.contributor.authorHerrera Castillón, Emilio
dc.date2002-
dc.date.accessioned2011-09-19T15:39:50Z
dc.date.available2011-09-19T15:39:50Z
dc.date.issued2002-09-19T15:39:50Z
dc.descriptionEn: International Journal of experimental diabetes research. 2002. n. 3 : 61-68 p. 1560-4284-
dc.description.abstractDiabetes mellitus is associated with a reduction of lipoprotein lipase (LPL) activity in adipose tissue and development of · hypertriglyceridemia. To determine how a condition of severe insulin deficiency affects mammary gland LPL activity and mRNA expression during late pregnancy, streptozotocin (STZ) treated (40 mg/kg) and non-treated (control) virgin and 20 day pregnant rats were studied. In control rats, both LPL activity and mRNA were higher in pregnant than in virgin rats. When compared to control rats, STZ-treated rats, either pregnant or virgin, showed decreased LPL activity and mRNA content. Furthermore, mammary gland LPL activity was linearly correlated with mRNA content, and either variable was linearly correlated with plasma insulin levels. Thus, insulin deficiency impairs the expression of LPL in mammary glands, revealing the role of insulin as a modulator of the enzyme at the mRNA expression level.en_EN
dc.formatapplication/pdf-
dc.identifier000000406641-
dc.identifier.urihttp://hdl.handle.net/10637/664
dc.language.isoen-
dc.rightsopen access
dc.rights.cchttps://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.rights.licensehttp://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subjectStreptozotocin diabetesen_EN
dc.subjectLipoprotein lipaseen_EN
dc.subjectMammary glanden_EN
dc.subjectPregnancyen_EN
dc.subjectmRNAen_EN
dc.subjectRaten_EN
dc.titleStreptozotocin-induced diabetes decreases mammary gland lipoprotein lipase activity and messenger ribonucleic acid in pregnant and nonpregnant rats.-
dc.typeArtículo-
dspace.entity.typePublicationes
europeana.dataProviderUNIVERSIDAD SAN PABLO CEU
europeana.isShownAthttp://hdl.handle.net/10637/664
europeana.objecthttp://repositorioinstitucional.ceu.es/visor/libros/406641/thumb_europeana/406641.jpg
europeana.providerHispana
europeana.rightshttp://creativecommons.org/publicdomain/zero/1.0/
europeana.typeTEXT
relation.isAuthorOfPublication05ccc1aa-254e-4ec7-a482-2b9e70f018b4
relation.isAuthorOfPublication.latestForDiscovery05ccc1aa-254e-4ec7-a482-2b9e70f018b4

Files

Original bundle

Now showing 1 - 1 of 1
Thumbnail Image
Name:
Streptozotocin_Blanco_et_al_Int_J_Exp_Dia_Res_2002.pdf
Size:
441.46 KB
Format:
Adobe Portable Document Format
Download

Collections

Facultad de Farmacia
x

The user has the obligation to use the services and content provided by the University, in particular, printed and electronic resources, in accordance with current legislation and the principles of good faith and generally accepted uses, without contravening with its performance the public order, especially, in the case in which, for the adequate performance of its activity, it needs to reproduce, distribute, communicate and/or make available, fragments of printed works or capable of being in analog or digital format, either on paper or electronic support. Law 23/2006, of July 7, which modifies the revised text of the Intellectual Property Law, approved by Royal Legislative Decree 1/1996, of April 12. B.O.E. n 162, of July 8, and concordant regulations.

@ 2024 Fundación Universitaria San Pablo CEU (Madrid). All rights reserved.

DSpace Software Copyright © 2002-2013 Duraspace