1. Investigación

¿Cómo un videojuego puede fracasar en su lanzamiento y, posteriormente, convertirse en un éxito gracias a la información extraída de la experiencia y opinión de los jugadores? El big data se ha integrado interdisciplinariamente en el ámbito de los videojuegos donde el uso de grandes cantidades de datos sobre las partidas de los gamers está presente en el proceso de conceptualización y desarrollo narrativo, así como en las decisiones de marketing y en la creación de nuevos productos y licencias. Ante este contexto, esta investigación analiza el uso del big data en el videojuego Star Wars Battlefront II (EA DICE, 2017), incluyendo expansiones, micropagos, contenidos descargables gratuitos y decisiones estratégicas que afectan al modo multijugador. Los resultados permiten concluir que el big data ayuda a identificar problemas y errores en los videojuegos, mantener una experiencia de juego estable y prolongar la vida útil de estos productos de ocio digital. Además, permite tomar decisiones estratégicas sobre futuros desarrollos, basándose en las interacciones de los jugadores

Chronic kidney disease (CKD) has been increasing over the last years, with a rate between 0.49% to 0.87% new cases per year. Currently, the number of affected people is around 850 million worldwide. CKD is a slowly progressive disease that leads to irreversible loss of kidney function, end-stage kidney disease, and premature death. Therefore, CKD is considered a global health problem, and this sets the alarm for necessary efficient prediction, management, and disease prevention. At present, modern computer analysis, such as in silico medicine (ISM), denotes an emergent data science that offers interesting promise in the nephrology field. ISM offers reliable computer predictions to suggest optimal treatments in a case-specific manner. In addition, ISM offers the potential to gain a better understanding of the kidney physiology and/or pathophysiology of many complex diseases, together with a multiscale disease modeling. Similarly, -omics platforms (including genomics, transcriptomics, metabolomics, and proteomics), can generate biological data to obtain information on gene expression and regulation, protein turnover, and biological pathway connections in renal diseases. In this sense, the novel patient-centered approach in CKD research is built upon the combination of ISM analysis of human data, the use of in vitro models, and in vivo validation. Thus, one of the main objectives of CKD research is to manage the disease by the identification of new disease drivers, which could be prevented and monitored. This review explores the wide-ranging application of computational medicine and the application of -omics strategies in evaluating and managing kidney diseases.