Browsing by Author "Sastre Gallego, Ana"

Se determinan los niveles plasmáticos de las vitaminas A y E en un grupo de 677 personas adultas, de edades comprendidas entre los 18 y 64 años pertenecientes al personal laboral del Hospital Ramón y Caja! de Madrid. la recogida de datos referentes a la ingesta dietética se efectuó mediante modelo de registro semanal. la valoración bioquímica de ambas vitaminas se realizó a través del sistema de HPLC. Encontramos diferencias significativas para las dos vitaminas, en ambos grupos, diferencias que no se explican sólo por los hábitos de alimentación. Presentamos un cuadro de valores referenciales para ambas vitaminas, por grupos de edad y sexo.

Background Plasma concentrations of vitamins A and E are positively correlated with those of concurrent lipids and, on the other hand, lipid levels are influenced by apolipoprotein E polymorphism. Therefore, the effect of this polymorphism on both vitamins was analysed in an adult population. Materials and methods Subjects were recruited from a working population. Their anthropometric, lifestyle and dietary intake variables and menopausal status were recorded. Their apolipoprotein E phenotype and their plasma vitamins A and E (by high-performance liquid chromatography) and lipid (enzymatically) concentrations were determined after an overnight fast. The associations of the phenotype with vitamins and lipids were studied in men and women separately and controlling for significant covariates. Results The apolipoprotein E phenotype was associated with the concentrations of total, low-density lipoprotein (LDL) and high-density lipoprotein (HDL) cholesterol in women, whereas no associations with lipids were found in men. Vitamin A and vitamin E levels were higher in men than in women, but only the difference in the former persisted after lipid adjustment. Apolipoprotein E2 slightly increased vitamin A levels in women, an effect which was still evident with lipid adjustment. Actually, both the apolipoprotein E phenotype and triglyceride were selected as significant predictors of this vitamin by multiple regression. This phenotype did not affect vitamin E levels in either sex. Conclusions Lipids do not mediate the effect of gender on vitamin A levels. Apolipoprotein E polymorphism is an independent determinant of vitamin A levels in women. Pending confirmation by others, we propose that enhancement of this vitamin may contribute to the beneficial impact of the E2 allele on human ageing and health.

Aunque la enfermedad cardiovascular sigue siendo la primera causa de muerte en nuestro país, la tasa de mortalidad en España es de las más bajas de Europa y, las estadísticas indican que se ha estabilizado en el último decenio. Esta, relativamer.te, baja tasa de mortalidad cardiovascular no se corresponde con un nivel de colesterol en plasma manifiestamente menor que en otros países, por lo que otros factores deben ser también considerados a la hora de establecer el riesgo cardiovascular de la población en general y del sujeto en particular. En el presente trabajo se recogen los datos preliminares de un estudio sobre hábitos de alimentación, prevalencia de hiperlipemia y otros factores asociados, tales como presión arterial y nivel de glucemia, en una población laboral activa, considerada sana, emprendido para analizar la situación de riesgo cardiovascular y su posible desvío con respecto a las recomendaciones internacionales.