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Capillary electrophoresis of glutathione to monitor oxidative stress and response to antioxidant treatments in an animal model.


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Título : Capillary electrophoresis of glutathione to monitor oxidative stress and response to antioxidant treatments in an animal model.
Autor : Maeso Nava, Nuria
García Martínez, Diana
Cifuentes, Alejandro
Barbas Arribas, Coral.
Rupérez Pascualena, Francisco Javier
Materias: Glutathione.Antioxidants.Oxidative stress.Rat.Blood.Liver.In vivo assay.
Resumen : Glutathione plays a central role in metabolism and antioxidant defence. Several factors can influence the analytical efficiency and rapidity of the quantitative determination of glutathione. Procedures in sample pre-treatment have been compared in order to minimize analytical errors. Capillary electrophoresis has been chosen as a more adequate technique for obtaining a rapid and simple method for glutathione and glutathione disulfide determination in the blood and liver of the rat. The methods, once optimised, have been validated and applied for monitoring the oxidative stress in an animal model, such as the rat made diabetic by streptozotocin injection, when the animals are treated with antioxidants and compared with the corresponding controls.
Descripción : En: Journal of chromatography B. 2005. vol. 822, n. 1-2 : 61-69 p. 0378-4348
Artículo en colaboración con: D. García-Martínez, F.J. Ruperez, A. Cifuentes, C. Barbas
URI : http://hdl.handle.net/10637/835
Derechos: http://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
Fecha de publicación : 19-sep-2005
Centro : Universidad San Pablo-CEU
Aparece en las colecciones: Facultad de Farmacia





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