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dc.creatorSaavedra, Luis-
dc.creatorHuidobro, Ángel Luis-
dc.creatorGarcía, Antonio-
dc.creatorCabanelas, José Carlos-
dc.creatorGonzález, María G.-
dc.creatorBarbas Arribas, Coral.-
dc.date2006-
dc.date.accessioned2011-09-19T15:39:22Z-
dc.date.available2011-09-19T15:39:22Z-
dc.date.issued2006-09-19T15:39:22Z-
dc.identifier000000450093-
dc.identifier.urihttp://hdl.handle.net/10637/765-
dc.descriptionEn: Electrophoresis, ISSN 1522-2683, 2006, 27 : 2360-2366 p.. ISSN 1522-2683-
dc.descriptionArtículo en colaboración con: Angel Luis Huidobro, Antonia García, Jose Carlos Cabanelas, María G. González, Coral Barbases-ES
dc.description.abstractThe control of degradation products is currently a critical issue to the pharmaceutical industry. A degradation product that appeared in alprazolam tablets during their stability assay, 7-chloro-1-methyl-5-phenyl-[1,2,4]triazolo[4,3-a]quinolin-4-amine, also named triazolaminoquinoline, was tested as possible candidate in the HPLC method employed for the study. The impurity showed the same retention time and spectra as the degradation product; but as all these compounds are very closely related, a confirmation with an independent technique was necessary, and CE was chosen for that purpose. Problems related to the adsorption of the analytes to the negatively charged silica surface were solved by employing a new polymeric capillary coating consisting of poly(3-aminopropylmethylsiloxane). The polymer provided EOF towards the anode, and the two compounds were separated in less than 8 min in a 60 cm total-length capillary, 75 mm id capillary with a BGE containing 50 mM phosphate buffer at pH 2.0 with 20% ACN. When the sample containing the degradation product was injected, the presence of triazolaminoquinoline was confirmed.en-EN
dc.formatapplication/pdf-
dc.language.isoen-
dc.rightshttp://creativecommons.org/licenses/by-nc-nd/4.0/deed.es-
dc.subjectCapillary coating.en-EN
dc.subjectImpurities.en-EN
dc.subjectPoly(3-aminopropylmethoxysilane.en-EN
dc.subjectPharmaceutical analysis.en-EN
dc.titleCE as orthogonal technique to HPLC for alprazolam degradation product identification.-
dc.typeArtículo-
europeana.dataProviderUNIVERSIDAD SAN PABLO CEU-
europeana.isShownAthttp://hdl.handle.net/10637/765-
europeana.objecthttp://repositorioinstitucional.ceu.es/visor/libros/450093/thumb_europeana/450093.jpg-
europeana.providerHispana-
europeana.rightshttp://creativecommons.org/publicdomain/zero/1.0/-
europeana.typeTEXT-
dc.centroUniversidad San Pablo-CEU-
Aparece en las colecciones: Facultad de Farmacia




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