Effects of streptozotocin-diabetes and L-thyroxine treatment on TSH and GH, and circulating glucose and glycerol in thyroidectomized rats.

Abstract

The response to exogenous thyroxine in ih; ro1<lectomi1~d rats made diabetic by treatment with ;trcpto7olocin was grea1I: impaired, a5 sho"n hy th~1r growth rdardation and the lack of increase in pb,ma GH and pituitary Gil and TSII COnffntrat1or.,. 2. Insulin administration panially compensated for ihcsc endocrine alterations in diabetic thyroidcctomized rats. When the,e animals received enough c\t1g:enous thyroxine to nonnalizc their plasma PBI and TSH kvcl,. insulin adn11111Stra1ion did nol de.:rease 1he1r augmented glucose and glycerol com:cntrations. 3. These findings show the pcrm,,,1vc action between thyroid hormones and insulin although some effects of the former counteract those of insulin.