Please use this identifier to cite or link to this item: http://hdl.handle.net/10637/578

Adipose tissue cellularity in hypo-and hyperthyroid rats

Title: Adipose tissue cellularity in hypo-and hyperthyroid rats
Authors : Muniesa, Ana
Herrera Castillón, Emilio.
Llobera i Sande, Miquel
Keywords: Adipose tissue cellularity.Hypothyroidism.Hyperthyroidism.
Abstract: To determine adipose tissue cellularity in hypo- and hyperthyroidism, male rats were thyroidectomized after weaning (T) and injected daily with either 0, 0.1, 1. 8, or 25 µg of L-thyroxine/100 g body weight for 40 days. They were compared with intact controls (C). Both epididymal fat-pad weight and adipocyte diameter were reduced in T+0, T+0.1 and T+25 animals. When corrected per unit of body weight, the diameters of adipocytes from T+0 and T+0. l animals were larger than in the other groups. Those same animals have reduced absolute adipocyte number but not when corrected per unit of body weight. The fat-pad protein concentration varied conversely with the fat cell diameter. These findings indicate that thyroid hormone deficiency reduces thf proliferation of fat cells in parallel with body growth while hyperthyroidism causes reduction in the size, but not the number, of fat cells which corresponds to its depletion of fat storage.
Description: En: Hormone Reseach, ISSN 0301-0163 1979. n. 11, pp 254-261
URI: http://hdl.handle.net/10637/578
Rights : http://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
Issue Date: 19-Sep-1979
Center : Universidad San Pablo-CEU
Appears in Collections:Facultad de Farmacia





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