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Evolution of oxidative stress parameters and response to oral vitamin E and C administration in streptozotocin diabetic rats.

Título : Evolution of oxidative stress parameters and response to oral vitamin E and C administration in streptozotocin diabetic rats.
Autor : Rupérez Pascualena, Francisco Javier
García Martínez, Diana
Baena, Beatriz
Maeso Nava, Nuria
Cifuentes, Alejandro
Barbas Arribas, Coral.
Herrera Castillón, Emilio.
Resumen : Type I diabetes in humans and streptozotocin (STZ)-induced diabetes in rats has been associated with oxidative stress, but antioxidant therapy has given contradictory results, in part related to the absence of common conditions used to evaluate in-vivo ant ioxidant properties. This prompted the study of an experimental model of antioxidant therapy in STZ-treated rats. Adult female rats received STZ (SOmgkg1 ) and were studied 7 or 14 days later. Adipose tissue weight progressively decreased with the time of treatment, whereas plasma triglycerides increased at 7 days, before returning to control values at 14 days after STZ treatment. STZ diabetic rats had increased plasma thiobarbituric acid reacting substances and o-tocopherol levels, but the latter variable was decreased when corrected for total lipids. STZ diabetic rats showed a higher GSSG/GSH ratio at Day 14 and lower GSH + GSSG at Day 7 in liver. To evaluate the effect of short-term antioxidant therapy, rats received 5 doses of vitamins C and E over 3 days before being killed on Day 14. Treatment with antioxidants decreased plasma lactic acid and thiobarbituric acid reacting substances, as well as urine 8-isoprostane. and decreased plasma uric acid in controls. Vitamins increased the plasma o:-tocopherol/lipids ratio only in control rats, although the plasma and liver o-tocopherol concentration increased in both groups. STZ diabetic rats showed moderate oxidative stress and treatment with antioxidant vitamins caused a significant change in a selected group of oxidative stress markers, which reflected an improvement in some of the complications associated with this disease. The present experimental conditions can be used as a sensitive experimental model to study the responsiveness of diabetes to other antioxidant interventions.
Descripción : En: Journal of pharacy and pharmacology 2008. n. 60 : 871-878 p. ISSN. 0022-3573
URI : http://hdl.handle.net/10637/2868
Derechos: http://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
Fecha de publicación : 19-sep-2008
Centro : Universidad San Pablo-CEU
Aparece en las colecciones: Facultad de Farmacia





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