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dc.creatorRupérez Pascualena, Francisco Javier-
dc.creatorGarcía Martínez, Diana-
dc.creatorBaena, Beatriz-
dc.creatorMaeso Nava, Nuria-
dc.creatorCifuentes, Alejandro-
dc.creatorBarbas Arribas, Coral.-
dc.creatorHerrera Castillón, Emilio.-
dc.date2008-
dc.date.accessioned2011-09-19T15:39:30Z-
dc.date.available2011-09-19T15:39:30Z-
dc.date.issued2008-09-19T15:39:30Z-
dc.identifier000000523936-
dc.identifier.urihttp://hdl.handle.net/10637/2868-
dc.descriptionEn: Journal of pharacy and pharmacology 2008. n. 60 : 871-878 p. ISSN. 0022-3573-
dc.description.abstractType I diabetes in humans and streptozotocin (STZ)-induced diabetes in rats has been associated with oxidative stress, but antioxidant therapy has given contradictory results, in part related to the absence of common conditions used to evaluate in-vivo ant ioxidant properties. This prompted the study of an experimental model of antioxidant therapy in STZ-treated rats. Adult female rats received STZ (SOmgkg1 ) and were studied 7 or 14 days later. Adipose tissue weight progressively decreased with the time of treatment, whereas plasma triglycerides increased at 7 days, before returning to control values at 14 days after STZ treatment. STZ diabetic rats had increased plasma thiobarbituric acid reacting substances and o-tocopherol levels, but the latter variable was decreased when corrected for total lipids. STZ diabetic rats showed a higher GSSG/GSH ratio at Day 14 and lower GSH + GSSG at Day 7 in liver. To evaluate the effect of short-term antioxidant therapy, rats received 5 doses of vitamins C and E over 3 days before being killed on Day 14. Treatment with antioxidants decreased plasma lactic acid and thiobarbituric acid reacting substances, as well as urine 8-isoprostane. and decreased plasma uric acid in controls. Vitamins increased the plasma o:-tocopherol/lipids ratio only in control rats, although the plasma and liver o-tocopherol concentration increased in both groups. STZ diabetic rats showed moderate oxidative stress and treatment with antioxidant vitamins caused a significant change in a selected group of oxidative stress markers, which reflected an improvement in some of the complications associated with this disease. The present experimental conditions can be used as a sensitive experimental model to study the responsiveness of diabetes to other antioxidant interventions.en_EN
dc.formatapplication/pdf-
dc.language.isoen-
dc.relationM EC projects AGL2005·06726-C04-03/ALI and AGL2004-06893-C02-01/ALI provided financial support.-
dc.rightshttp://creativecommons.org/licenses/by-nc-nd/4.0/deed.es-
dc.titleEvolution of oxidative stress parameters and response to oral vitamin E and C administration in streptozotocin diabetic rats.-
dc.typeArtículo-
europeana.dataProviderUNIVERSIDAD SAN PABLO CEU-
europeana.isShownAthttp://hdl.handle.net/10637/2868-
europeana.objecthttp://repositorioinstitucional.ceu.es/visor/libros/523936/thumb_europeana/523936.jpg-
europeana.providerHispana-
europeana.rightshttp://creativecommons.org/publicdomain/zero/1.0/-
europeana.typeTEXT-
dc.centroUniversidad San Pablo-CEU-
Aparece en las colecciones: Facultad de Farmacia




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