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dc.contributor.otherProducción Científica UCH 2024-
dc.contributor.otherUCH. Departamento de Medicina y Cirugía Animal-
dc.contributor.otherUCH. Grupo de Investigación en "Medicina Biorregenerativa y Cirugía Aplicada (BIOMED-SURGERY)"-
dc.creatorMiguel Pastor, Laura-
dc.creatorSatué Ambrojo, Katiuska-
dc.creatorChicharro Alcántara, Deborah-
dc.creatorDamiá Giménez, Elena-
dc.creatorCuervo Serrato, Belén-
dc.creatorTorres Torrillas, Marta-
dc.creatorMartins, Emma Julie Camille-
dc.creatorVelasco Martínez, María Gemma-
dc.creatorCarrillo Poveda, José María-
dc.creatorSopena Juncosa, Joaquín Jesús-
dc.creatorCerón, José J.-
dc.creatorRubio Zaragoza, Mónica-
dc.date.accessioned2024-06-03T18:08:43Z-
dc.date.available2024-06-03T18:08:43Z-
dc.date.issued2024-03-
dc.identifier.citationMiguel-Pastor, L., Satué, K., Chicharro, D., Damiá, E., Cuervo, B., Torres-Torrillas, M., Martins, E., Velasco-Martínez, M.G., Carrillo, J.M., Sopena, J.J., Cerón, J.J. & Rubio, M. (2024). Characterization of platelet rich plasma in feline immunodeficiency virus-infected cats: cell, and PDGF-BB and TGF-ß1 growth factor analysis. Research in Veterinary Science, vol. 168 (mar.), art. 105138. DOI: https://doi.org/10.1016/j.rvsc.2024.105138es_ES
dc.identifier.issn0034-5288-
dc.identifier.issn1532-2661 (Electrónico)-
dc.identifier.urihttp://hdl.handle.net/10637/15896-
dc.description.abstractAutologous platelet-rich plasma (PRP) contains growth factors (GFs) that modulate the expression of inflammatory cells; thus, these products could be considered a good strategy to favor tissue regeneration in feline immunodeficiency (FIV) positive cats. However, there is no scientific documentation on obtaining PRP in FIV-positive cats. Authors hypothesized that PRP can be obtained in FIV cats following the PRGF®-Endoret® methodology. The objectives of this study were to compare the platelet, erythrocyte, and leukocyte concentration between whole blood (WB) and the PRP; and determine the concentration of platelet-derived growth factor BB (PDGF-BB) and transforming growth factor β1 (TGF-β1) in FIV-positive cats. Sixteen adults FIV-positive asymptomatic cats were included in the study. WB samples were drawn and the PRP was obtained by centrifugation at 265g for 10 min. Erythrocyte and leukocyte, platelets, and mean platelet volume (MPV) were determined both in WB and in PRP. PDGF-BB and TGF-β1 concentrations were additionally determined in PRP. Platelet concentration increased 1.1 times in PRP fraction compared to WB, but no significant differences were reported. MPV was statistically higher in WB than in PRP (p = 0.001). Erythrocytes and leukocytes counts were decreased by 99% and 92%, respectively in the PRP fraction (p < 0.001). Regarding TGF-ß1, a higher concentration was shown in the PRP (p < 0.02). Although the product obtained could not be classified as PRP according to the PRGF®-Endoret® methodology, based on the drastic reduction of RBC and WBC, the PLT concentrate is of high purity.es_ES
dc.description.sponsorshipAcuerdo Transformativo – 2024-
dc.language.isoenes_ES
dc.publisherElsevieres_ES
dc.relationEste artículo de investigación ha sido financiado por la Universidad CEU Cardenal Herrera (INDI 21/54 e INDI 22/53).-
dc.relationUCH. Financiación Universidad-
dc.relation.ispartofResearch in Veterinary Science, vol. 168 (mar.)-
dc.rightshttp://creativecommons.org/licenses/by-nc/4.0/deed.es-
dc.rightsOpen Access-
dc.subjectPlasma sanguíneoes_ES
dc.subjectBlood plasmaes_ES
dc.subjectPlaquetases_ES
dc.subjectBlood plateletses_ES
dc.subjectFactores de crecimientoes_ES
dc.subjectGrowth factorses_ES
dc.subjectGatoes_ES
dc.subjectCatses_ES
dc.subjectEnfermedad animales_ES
dc.subjectAnimal diseaseses_ES
dc.titleCharacterization of platelet rich plasma in feline immunodeficiency virus-infected cats: cell, and PDGF-BB and TGF-ß1 growth factor analysises_ES
dc.typeArtículoes_ES
dc.identifier.doihttps://doi.org/10.1016/j.rvsc.2024.105138-
dc.relation.projectIDINDI21/54-
dc.relation.projectIDINDI22/53-
dc.centroUniversidad Cardenal Herrera-CEU-
Aparece en las colecciones: Dpto. Medicina y Cirugía Animal




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