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Characterisation of experimental flowable composites containing fluoride-doped calcium phosphates as promising remineralising materials


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Título : Characterisation of experimental flowable composites containing fluoride-doped calcium phosphates as promising remineralising materials
Autor : Alambiaga Caravaca, Adrián Miguel
Chou, Yu Fu
Moreno, Daniel
Aparicio, Conrado
López Castellano, Alicia Cristina
Feitosa, Victor Pinheiro
Tezvergil-Mutluay, Arzu
Sauro, Salvatore
Materias: OdontologíaDentistryMaterial compuestoComposite materials
Editorial : Elsevier
Citación : Alambiaga-Caravaca, A.M., Chou, Y.F., Moreno, D., Aparicio, C., López-Castellano, A., Feitosa, V.P., Tezvergil-Mutluay, A. & Sauro, S. (2024). Characterisation of experimental flowable composites containing fluoride-doped calcium phosphates as promising remineralising materials. Journal of Dentistry, vol. 143 (apr.), art. 104906. DOI: https://doi.org/10.1016/j.jdent.2024.104906
Resumen : Objective: Remineralising composites with antibacterial properties may seal the cavity and prevent secondary caries. This study aimed at developing experimental flowable composites containing different concentrations of fluoride-doped calcium phosphate fillers and evaluating their remineralising and antibacterial properties. Methods: Experimental resin-based composites containing different concentrations (0–20 %) of fluoride-doped calcium phosphate fillers (VS10/VS20) were formulated. The release of calcium (Ca), phosphate (PO) and fluoride (F) ions was assessed for 30 days. Remineralisation properties were evaluated through ATR-FTIR and SEM/EDX after storage in simulated body fluid (SBF). The metabolic activity and viability of Streptococcus gordonii was also evaluated through ATP, CFU and live/dead confocal microscopy. The evaluation of specific monomer elution from the experimental composites was conducted using high-performance liquid chromatography (HPLC). Results: The composites containing VS10 showed the highest release of Ca, those containing VS20 released more F over time (p < 0.05), while there was no significant difference in terms of PO ions release between the groups (p > 0.05). A quick 7-day mineral precipitation was observed in the tested composites containing VS10 or VS20 at 10 %; these materials also showed the greatest antibacterial activity (p < 0.05). Moreover, the tested composites containing VS10 presented the lowest elution of monomers (p < 0.05). Conclusions: Innovative composites were developed with low monomers elution, evident antibacterial activity against S. gordonii and important remineralisation properties due to specific ions release. Clinical significance: Novel composites containing fluoride-doped calcium phosphates may be promising to modulate bacteria growth, promote remineralisation and reduce the risk of cytotoxicity related to monomers’ elution.
Descripción : Este artículo ha generado una patente (ES2716942 - Composición y procedimiento para la obtención y aplicación de un compuesto bioactivo que contiene fluoruro y el producto obtenido).
URI : http://hdl.handle.net/10637/15890
Derechos: http://creativecommons.org/licenses/by-nc/4.0/deed.es
Open Access
ISSN : 0300-5712
1879-176X (Electrónico)
Cubierto por: Acuerdo Transformativo – 2024
Fecha de publicación : abr-2024
Centro : Universidad Cardenal Herrera-CEU
Aparece en las colecciones: Dpto. Odontología





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