Please use this identifier to cite or link to this item: http://hdl.handle.net/10637/15315

Non-IgE-Mediated Gastrointestinal Food Protein-Induced Allergic Disorders. Clinical Perspectives and Analytical Approaches


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Title: Non-IgE-Mediated Gastrointestinal Food Protein-Induced Allergic Disorders. Clinical Perspectives and Analytical Approaches
Authors : Zubeldia Varela, Elisa
Barker Tejeda, Tomas Clive
Blanco-Pérez, Frank
Infante, Sonsoles
Zubeldia, José M.
Pérez Gordo, Marina
Keywords: Food allergyNon-IgE-mediated gastrointestinal food allergyCow’s milkFood proteininduced enterocolitis syndromeFood protein-induced allergic proctocolitisFood protein-induced enteropathyFecal calprotectinOmics
Publisher: MDPI
Citation: Zubeldia-Varela, E., Barker-Tejeda, T. C., Blanco-Pérez, F., Infante, S., Zubeldia, J. M., & Pérez-Gordo, M. (2021). Non-IgE-Mediated Gastrointestinal Food Protein-Induced Allergic Disorders. Clinical Perspectives and Analytical Approaches. Foods (Basel, Switzerland), 10(11), 2662. https://doi.org/10.3390/foods10112662
Abstract: Non-IgE-mediated gastrointestinal food allergy (non-IgE-GI-FA) is the name given to a series of pathologies whose main entities are food protein-induced allergic proctocolitis (FPIAP), food protein-induced enteropathy (FPE), and food protein-induced enterocolitis syndrome (FPIES). These are more uncommon than IgE-mediated food allergies, their mechanisms remain largely unknown, and their diagnosis is mainly done by clinical history, due to the lack of specific biomarkers. In this review, we present the latest advances found in the literature about clinical aspects, the current diagnosis, and treatment options of non-IgE-GI-FAs. We discuss the use of animal models, the analysis of gut microbiota, omics techniques, and fecal proteins with a focus on understanding the pathophysiological mechanisms of these pathologies and obtaining possible diagnostic and/or prognostic biomarkers. Finally, we discuss the unmet needs that researchers should tackle to advance in the knowledge of these barely explored pathologies.
URI: http://hdl.handle.net/10637/15315
Rights : http://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
Open Access
ISSN: 2304-8158
Issue Date: 2-Nov-2021
Center : Universidad San Pablo-CEU
Appears in Collections:Medicina





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