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EAACI Biologicals Guidelines-Recommendations for severe asthma


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Title: EAACI Biologicals Guidelines-Recommendations for severe asthma
Authors : Agache, Ioana
Akdis, Cezmi A.
Akdis, Mubeccel
Canonica, Giorgio Walter
Casale, Thomas
Chivato Pérez, Tomás
Corren, Jonathan
Chu, D. K.
Giacco, Stefano del
Eiwegger, Thomas
Flood, B.
Firinu, Davide
Gern, James E.
Hamelmann, Eckard
Hanania, Nicola
Hernández Martín, Irene
Knibb, R.
Mäkelä, Mika
Nair, P.
O'Mahony, Liam
Papadopoulos, Nikolaos G.
Papi, Alberto
Park, Hae-Sim
Pérez de Llano, Luis
Pfaar, Oliver
Quirce, Santiago
Sastre, Joaquín
Shamji, Mohamed
Schwarze, Jürgen
Palomares, Oscar
Jutel, Marek
Keywords: BiologicalsCost-effectivenessGRADEGuidelinesSevere asthma
Publisher: Wiley
Citation: Agache I, Akdis C, Akdis M, et al. EAACI Biologicals Guidelines—Recommendations for severe asthma. Allergy. 2021;76:14–44. https://doi.org/10.1111/all.14425
Abstract: Severe asthma imposes a significant burden on patients, families and healthcare systems. Management is difficult, due to disease heterogeneity, co-morbidities, complexity in care pathways and differences between national or regional healthcare systems. Better understanding of the mechanisms has enabled a stratified approach to the management of severe asthma, supporting the use of targeted treatments with biologicals. However, there are still many issues that require further clarification. These include selection of a certain biological (as they all target overlapping disease phenotypes), the definition of response, strategies to enhance the responder rate, the duration of treatment and its regimen (in the clinic or home-based) and its costeffectiveness. The EAACI Guidelines on the use of biologicals in severe asthma follow the GRADE approach in formulating recommendations for each biological and each outcome. In addition, a management algorithm for the use of biologicals in the clinic is proposed, together with future approaches and research priorities.
URI: http://hdl.handle.net/10637/15126
Rights : http://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
ISSN: 1398-9995
Issue Date: 2020
Center : Universidad San Pablo-CEU
Appears in Collections:Medicina





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