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Rnd3 is necessary for the correct oligodendrocyte differentiation and myelination in the central nervous system


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Título : Rnd3 is necessary for the correct oligodendrocyte differentiation and myelination in the central nervous system
Autor : Madrigal Verdú, Pilar
Ballester Lurbe, Begoña
Gómez Roda, Olga
Moreno Bravo, Juan Antonio
Puelles, E.
Jurado Sánchez, Sandra
García Verdugo, José Manuel
Pérez Roger, Ignacio
Terrado Vicente, José
Materias: Sistema nervioso central.Central nervous system.Proteínas.Myelin sheath.Células.Cells.Mielina.Proteins.
Editorial : Springer Nature.
Citación : Madrigal, M.P., Ballester-Lurbe, B., Gómez, O., Moreno-Bravo, J.A., Puelles, E., Jurado, S. et al. (2022). Rnd3 is necessary for the correct oligodendrocyte differentiation and myelination in the central nervous system. Brain Structure and Function, vol. 227, i. 3 (01 apr.), pp. 829-841. DOI: https://doi.org/10.1007/s00429-021-02419-0
Resumen : Rho small GTPases are proteins with key roles in the development of the central nervous system. Rnd proteins are a subfamily of Rho GTPases characterized by their constitutive activity. Rnd3/RhoE is a member of this subfamily ubiquitously expressed in the CNS, whose specific functions during brain development are still not well defined. Since other Rho proteins have been linked to the myelination process, we study here the expression and function of Rnd3 in oligodendrocyte development. We have found that Rnd3 is expressed in a subset of oligodendrocyte precursor cells and of mature oligodendrocytes both in vivo and in vitro. We have analyzed the role of Rnd3 in myelination using mice lacking Rnd3 expression (Rnd3gt/gt mice), showing that these mice exhibit hypomyelination in the brain and a reduction in the number of mature and total oligodendrocytes in the corpus callosum and striatum. The mutants display a decreased expression of several myelin proteins and a reduction in the number of myelinated axons. In addition, myelinated axons exhibit thinner myelin sheaths. In vitro experiments using Rnd3gt/gt mutant mice showed that the differentiation of the precursor cells is altered in the absence of Rnd3 expression, suggesting that Rnd3 is directly required for the differentiation of oligodendrocytes and, in consequence, for the correct myelination of the CNS. This work shows Rnd3 as a new protein involved in oligodendrocyte maturation, opening new avenues to further study the function of Rnd3 in the development of the central nervous system and its possible involvement in demyelinating diseases.
Descripción : Este artículo se encuentra disponible en la siguiente URL: https://link.springer.com/article/10.1007/s00429-021-02419-0
This is a post-peer-review, pre-copyedit version of an article published in Madrigal, MP., Ballester-Lurbe, B., Gómez, O., Moreno-Bravo, JA., Puelles, E., Jurado, S., Garcia-Verdugo, JM., Pérez-Roger, I. & Terrado, J. (2022). Rnd3 is necessary for the correct oligodendrocyte differentiation and myelination in the central nervous system. Brain Structure and Function, vol. 227, i. 3 (01 apr.), pp. 829-841. The final authenticated version is available online at: http://dx.doi.org/10.1007/s00429-021-02419-0.
Este es el post-print del siguiente artículo: Madrigal, MP., Ballester-Lurbe, B., Gómez, O., Moreno-Bravo, JA., Puelles, E., Jurado, S., Garcia-Verdugo, JM., Pérez-Roger, I. & Terrado, J. (2022). Rnd3 is necessary for the correct oligodendrocyte differentiation and myelination in the central nervous system. Brain Structure and Function, vol. 227, i. 3 (01 apr.), pp. 829-841, que se ha publicado de forma definitiva en http://dx.doi.org/10.1007/s00429-021-02419-0
URI : http://hdl.handle.net/10637/13197
Derechos: http://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
ISSN : 1863-2653.
1863-2661 (Electrónico)
Fecha de publicación : 1-abr-2022
Centro : Universidad Cardenal Herrera-CEU
Aparece en las colecciones: Dpto. Medicina y Cirugía Animal





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