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Therapeutic doses of plasma rich in growth factors cannot provoke cancer by means of the IGF-1 pathway or inflammation in dogs


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Title: Therapeutic doses of plasma rich in growth factors cannot provoke cancer by means of the IGF-1 pathway or inflammation in dogs
Authors : Vilar, José M.
Damiá Giménez, Elena
Rubio Zaragoza, Mónica.
Santana, Angelo
Sopena Juncosa, Joaquín Jesús.
Cerón Madrigal, José Joaquín
Tvarijonaviciute, Asta
Cugat Bertomeu, Ramón
Carrillo Poveda, José María.
Keywords: Crecimiento - Factores - Uso terapéutico.Growth factors - Therapeutic use.Cancer in dogs - Risk factors.Plasma sanguíneo - Uso terapéutico.Cáncer en los perros - Factores de riesgo.Blood plasma - Therapeutic use.
Publisher: Informa UK.
Citation: Vilar, JM., Damiá, E., Rubio, M., Santana, A., Sopena, J., Ceron, J. (2017). Therapeutic doses of plasma rich in growth factors cannot provoke cancer by means of the IGF-1 pathway or inflammation in dogs. Journal of Applied Animal Research, vol. 45, n. 1, pp. 490-493. DOI: https://doi.org/10.1080/09712119.2016.1218888
Abstract: A potential relationship between an increased risk of cancer and increased levels of serum insulin-like growth factor-1 (IGF-1), and presence of cancer and high levels of C-reactive protein (CRP) has been previously reported. This study evaluated the influence of a single intramuscular injection of plasma rich in growth factors (PRGF) on serum concentrations of IGF-1 and CRP in dogs. Two groups of eight healthy beagles were injected with two different doses of PRGF in lumbar muscles. For each treatment, IGF-1 and CRP were analysed from blood samples obtained at baseline and the following three days post injection. No differences were found when IGF-1 and CRP were compared among times in the two protocols. Local application of PRGF at clinical doses did not cause significant changes in systemic concentrations of IGF-1 or detectable inflammation.
Description: Este artículo se encuentra disponible en la siguiente URL: https://www.tandfonline.com/doi/full/10.1080/09712119.2016.1218888
URI: http://hdl.handle.net/10637/10595
Rights : http://creativecommons.org/licenses/by/4.0/deed.es
ISSN: 0971-2119
0974-1844 (Electrónico)
Issue Date: 25-Jan-2017
Center : Universidad Cardenal Herrera-CEU
Appears in Collections:Dpto. Medicina y Cirugía Animal





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