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The contribution of alpha-2 adrenoceptor and opioid receptor mechanisms to antinociception differs in Lewis and Fischer 344 rats.

Título : The contribution of alpha-2 adrenoceptor and opioid receptor mechanisms to antinociception differs in Lewis and Fischer 344 rats.
Autor : Herradón Gil-Gallardo, Gonzalo
Morales Goyanes, Lydia
Pérez-García, Carmen
Alguacil Merino, Luis Fernando
Materias: AntinociceptionLewis ratF344 ratMorphineYohimbineClonidine
Resumen : Lewis and Fischer 344 (F344) rats differ in their physiological and pharmacological responses to a variety of environmental stimuli, which have been partially attributed to endogenous opioid function. Since opioid and a2-adrenoceptor mechanisms are closely related, we have comparatively examined the contribution of both systems to antinociception in female Lewis and F344 rats by the tail-flick method. Basal responses of F344 and Lewis rats were found to be similar, both showing a slight but significant increase in reaction time along the experimental period which was not completely reversed by naloxone. Morphine exhibited a bell-shaped dose–response curve in Lewis rats, these animals being more sensitive than F344 at 1 and 5 mg/kg but less sensitive at 10 mg/kg. Clonidine up to 0.1 mg/kg was more active in F344 rats. The a2-adrenoceptor antagonist yohimbine provoked a higher hyperalgesic effect in Lewis rats and decreased morphine antinociception in both strains. The existence of a balanced contribution of opioid and a2-adrenoceptor mechanisms to control pain transmission in both strains is discussed.
Descripción : En: European journal of pharmacology. ISSN 0014-2999. v. 465 (2003), p. 251-256
URI : http://hdl.handle.net/10637/1015
Derechos: http://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
Fecha de publicación : 19-sep-2011
Centro : Universidad San Pablo-CEU
Aparece en las colecciones: Facultad de Farmacia





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