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dc.creatorHerradón Gil-Gallardo, Gonzalo-
dc.creatorMorales Goyanes, Lydia-
dc.creatorPérez-García, Carmen-
dc.creatorAlguacil Merino, Luis Fernando-
dc.date2003-
dc.date.accessioned2011-09-19T15:40:26Z-
dc.date.available2011-09-19T15:40:26Z-
dc.date.issued2011-09-19T15:40:26Z-
dc.identifier000000463119-
dc.identifier.urihttp://hdl.handle.net/10637/1015-
dc.descriptionEn: European journal of pharmacology. ISSN 0014-2999. v. 465 (2003), p. 251-256-
dc.description.abstractLewis and Fischer 344 (F344) rats differ in their physiological and pharmacological responses to a variety of environmental stimuli, which have been partially attributed to endogenous opioid function. Since opioid and a2-adrenoceptor mechanisms are closely related, we have comparatively examined the contribution of both systems to antinociception in female Lewis and F344 rats by the tail-flick method. Basal responses of F344 and Lewis rats were found to be similar, both showing a slight but significant increase in reaction time along the experimental period which was not completely reversed by naloxone. Morphine exhibited a bell-shaped dose–response curve in Lewis rats, these animals being more sensitive than F344 at 1 and 5 mg/kg but less sensitive at 10 mg/kg. Clonidine up to 0.1 mg/kg was more active in F344 rats. The a2-adrenoceptor antagonist yohimbine provoked a higher hyperalgesic effect in Lewis rats and decreased morphine antinociception in both strains. The existence of a balanced contribution of opioid and a2-adrenoceptor mechanisms to control pain transmission in both strains is discussed.en-EN
dc.formatapplication/pdf-
dc.language.isoen-
dc.rightshttp://creativecommons.org/licenses/by-nc-nd/4.0/deed.es-
dc.subjectAntinociceptionen-EN
dc.subjectLewis raten-EN
dc.subjectF344 raten-EN
dc.subjectMorphineen-EN
dc.subjectYohimbineen-EN
dc.subjectClonidineen-EN
dc.titleThe contribution of alpha-2 adrenoceptor and opioid receptor mechanisms to antinociception differs in Lewis and Fischer 344 rats.-
dc.typeArtículo-
europeana.dataProviderUNIVERSIDAD SAN PABLO CEU-
europeana.isShownAthttp://hdl.handle.net/10637/1015-
europeana.objecthttp://repositorioinstitucional.ceu.es/visor/libros/463119/thumb_europeana/463119.jpg-
europeana.providerHispana-
europeana.rightshttp://creativecommons.org/publicdomain/zero/1.0/-
europeana.typeTEXT-
dc.centroUniversidad San Pablo-CEU-
Aparece en las colecciones: Facultad de Farmacia




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