Por favor, use este identificador para citar o enlazar este ítem: http://hdl.handle.net/10637/9990
Título : Can plasma rich in growth factors be safe for parental use? : a safety study in the canine model / Elena Damiá, Deborah Chicharro, Mónica Rubio, José M. Carrillo, Joaquín Sopena, Belén Cuervo, Sergio López and José M. Vilar.
Autor : Damiá Giménez, Elena.
Chicharro Alcántara, Deborah.
Rubio Zaragoza, Mónica.
Carrillo Poveda, José María.
Sopena Juncosa, Joaquín Jesús.
Cuervo Serrato, Belén.
López Barbeta, Sergio.
Vilar, José M.
Palabras clave : Blood plasma - Therapeutic use.
Crecimiento - Factores - Uso terapéutico.
Plasma sanguíneo - Uso terapéutico.
Dogs.
Insuline - Therapeutic use - Testing.
Insulina - Uso terapéutico - Ensayos clínicos.
Perros.
Growth factors - Therapeutic use.
Fecha de publicación : 11-sep-2018
Editorial : MDPI.
Citación : Damiá, E., Chicharro, D., Rubio, M., Carrillo, JM., Sopena, J., Cuervo, B., López, S. and Vilar, JM. (2018). Can plasma rich in growth factors be safe for parental use? : a safety study in the canine model. International Journal of Molecular Sciences, vol. 19, n. 9, art. 2701. DOI: https://doi.org/10.3390/ijms19092701
Resumen : Low invasiveness is the main goal of modern surgery. The use of platelet-rich plasma (PRP) is known to be effective in a variety of applications, such as oral, maxillofacial, orthopedic, dermatologic and cosmetic surgeries. However, a potential ergogenic and carcinogenic effect of PRP derivatives by means of the insulin-like growth factor-1 (IGF-1) pathway has been suggested. Because of this notion, the purpose of this study is to assess the effect of a commercially available PRP-derivative intramuscular injection in the lumbar muscular tissue (local effect) and to determine the IGF-1 blood concentration (systemic effect) on healthy beagle dogs. Local effect was evaluated by computed tomography (CT) scan and echography, and systemic effect was calculated by blood testing on days 0, 14, 28, 42 and 56. No statistically significant changes were observed; thus, PRGF could be considered safe when using therapeutic doses.
Descripción : Este artículo se encuentra disponible en la página web de la revista en la siguiente URL: https://www.mdpi.com/1422-0067/19/9/2701
URI : http://hdl.handle.net/10637/9990
ISSN : 1422-0067.
Aparece en las colecciones: Dpto. Medicina y Cirugía Animal




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