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dc.creatorGarcía Ruíz, Carmenes
dc.creatorCrego, Antonio L.-
dc.creatorLavandera Díaz, José Luis-
dc.creatorMarina, María Luisa-
dc.date2001es
dc.date.accessioned2013-11-01T05:00:25Z-
dc.date.available2013-11-01T05:00:25Z-
dc.date.issued2001-11-01-
dc.identifier000000580879es
dc.identifier.urihttp://hdl.handle.net/10637/5544-
dc.descriptionEn: Electrophoresis. ISSN 0173-0835. v. 22, 2001, págs 2775-2781es
dc.description.abstractA mixture of five tetracycline (TC) derivatives: minocycline (MC), demeclocycline (DMCTC), doxycycline (DC), and sancycline (SC), as well as each TC derivative from its main degradation product were separated by capillary zone electrophoresis (CZE). The influence of the pH and the concentration and nature of the background electrolyte (BGE) on the separations was investigated. Ethylenediaminetetraacetic acid (EDTA; 1mM) was used as additive in a 25 mM phosphate buffer (pH 2.3) because this BGE enabled the rapid separation of the TC derivatives and of each TC derivative from its respective degradation product in less than 6 min. After optimization of the separation conditions, the analytical characteristics of the method were investigated. The parameters involved were linearity, precision (repeatability and reproducibility), and limits of detection (LODs). LODs obtained for the five TC derivatives studied were about 3 g/mL. Finally, the CZE method developed was applied to study the stability of TC derivatives and to analyze the TC derivative content in three different pharmaceutical preparations.en_EN
dc.formatapplication/pdfes
dc.language.isoenes
dc.rightshttp://creativecommons.org/licenses/by-nc-nd/4.0/deed.eses
dc.subjectCompuestos heterocíclicos.es
dc.subjectTetracyclinesen_EN
dc.subjectMethod developmenten_EN
dc.subjectOptimizationen_EN
dc.titleRapid separation of tetracycline derivatives and their main degradation products by capillary zone electrophoresises
dc.typeArtículoes
europeana.dataProviderUNIVERSIDAD SAN PABLO CEU-
europeana.isShownAthttp://hdl.handle.net/10637/5544-
europeana.objecthttp://repositorioinstitucional.ceu.es/visor/libros/580879/thumb_europeana/580879.jpg-
europeana.providerHispana-
europeana.rightshttp://creativecommons.org/publicdomain/zero/1.0/-
europeana.typeTEXT-
dc.centroUniversidad San Pablo-CEU-
Aparece en las colecciones: Medicina




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