Please use this identifier to cite or link to this item: http://hdl.handle.net/10637/15350
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dc.contributor.otherUniversidad San Pablo-CEU. Facultad de Medicina. Departamento de Ciencias Médicas Clínicas.-
dc.contributor.otherGrupo: HM Centro Integral de Neurociencia (HM CINAC)-
dc.contributor.otherCentro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED)-
dc.creatorPineda-Pardo, José A.-
dc.creatorGasca Salas, Carmen-
dc.creatorFernández-Rodríguez, Beatriz-
dc.creatorRodríguez Rojas, Rafael-
dc.creatorÁlamo, Marta del-
dc.creatorObeso Martín, Ignacio-
dc.creatorHernández-Fernández, Frida-
dc.creatorTrompeta, Clara-
dc.creatorMartínez-Fernández, Raúl-
dc.creatorMatarazzo, Michele-
dc.creatorMata-Marín, David-
dc.creatorGuida, Pasqualina-
dc.creatorDuque, Alicia-
dc.creatorAlbillo, David-
dc.creatorPlaza de las Heras, Isabel-
dc.creatorMontero Roblas, Juan Ignacio-
dc.creatorFoffani, Guglielmo-
dc.creatorToltsis, Gabriella-
dc.creatorRachmilevitch, Itay-
dc.creatorBlesa de los Mozos, Francisco Javier-
dc.creatorObeso Inchausti, José Ángel-
dc.date.accessioned2024-02-05T14:42:02Z-
dc.date.available2024-02-05T14:42:02Z-
dc.date.issued2022-06-28-
dc.identifier.citationPineda-Pardo JA, Gasca-Salas C, Fernández-Rodríguez B, Rodríguez-Rojas R, Del Álamo M, Obeso I, Hernández-Fernández F, Trompeta C, Martínez-Fernández R, Matarazzo M, Mata-Marín D, Guida P, Duque A, Albillo D, Plaza de Las Heras I, Montero JI, Foffani G, Toltsis G, Rachmilevitch I, Blesa J, Obeso JA. Striatal Blood-Brain Barrier Opening in Parkinson's Disease Dementia: A Pilot Exploratory Study. Mov Disord. 2022 Oct;37(10):2057-2065. doi: 10.1002/mds.29134.es_ES
dc.identifier.issn0885-3185-
dc.identifier.urihttp://hdl.handle.net/10637/15350-
dc.description.abstractBackground: Parkinson's disease (PD) exhibits a high prevalence of dementia as disease severity and duration progress. Focused ultrasound (FUS) has been applied for transient blood-brain barrier (BBB) opening of cortical regions in neurodegenerative disorders. The striatum is a primary target for delivery of putative therapeutic agents in PD. Objective: Here, we report a prospective, single-arm, nonrandomized, proof-of-concept, phase I clinical trial (NCT03608553 amended) in PD with dementia to test the safety and feasibility of striatal BBB opening in PD patients. Methods: Seven PD patients with cognitive impairment were treated for BBB opening in the posterior putamen. This was performed in two sessions separated by 2 to 4 weeks, where the second session included bilateral putamina opening in 3 patients. Primary outcome measures included safety and feasibility of focal striatal BBB opening. Changes in motor and cognitive functions, magnetic resonance imaging (MRI), 18 F-fluorodopa (FDOPA), and β-amyloid PET (positron emission tomography) images were determined. Results: The procedure was feasible and well tolerated, with no serious adverse events. No neurologically relevant change in motor and cognitive (battery of neuropsychological tests) functions was recognized at follow-up. MRI revealed putamen BBB closing shortly after treatment (24 hours to 14 days) and ruled out hemorrhagic and ischemic lesions. There was a discrete but significant reduction in β-amyloid uptake in the targeted region and no change in FDOPA PET. Conclusions: These initial results indicate that FUS-mediated striatal BBB opening is feasible and safe and therefore could become an effective tool to facilitate the delivery of putative neurorestorative molecules in PD. © 2022 International Parkinson and Movement Disorder Society.en_EN
dc.formatapplication/pdf-
dc.language.isoen-
dc.publisherWiley-
dc.relation.ispartofMovement Disorders-
dc.rightshttp://creativecommons.org/licenses/by-nc-nd/4.0/deed.es-
dc.subjectParkinson's diseaseen_EN
dc.subjectFocused ultrasounden_EN
dc.subjectTransient blood-brain barrieren_EN
dc.subjectStriatal neuronsen_EN
dc.titleStriatal Blood–Brain Barrier Opening in Parkinson’s Disease Dementia: A Pilot Exploratory Studyen_EN
dc.typeArtículoes_ES
dc.identifier.doi10.1002/mds.29134-
dc.relation.projectIDSupported by Plan Nacional Ministerio de Educaci on y Ciencias PID2019 111045RB-I00 (Government of Spain), a grant from MAPFRE Foundation, and a joint project between Fundaci on Hospitales de Madrid and Insightec Ltd. Dr. Javier Blesa is currently funded by Instituto de Salud Carlos III Miguel Servet Program (CP19/00200) and FIS (PI20/00496).-
dc.centroUniversidad San Pablo-CEU-
Appears in Collections:Medicina




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