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http://hdl.handle.net/10637/15350
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DC Field | Value | Language |
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dc.contributor.other | Universidad San Pablo-CEU. Facultad de Medicina. Departamento de Ciencias Médicas Clínicas. | - |
dc.contributor.other | Grupo: HM Centro Integral de Neurociencia (HM CINAC) | - |
dc.contributor.other | Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED) | - |
dc.creator | Pineda-Pardo, José A. | - |
dc.creator | Gasca Salas, Carmen | - |
dc.creator | Fernández-Rodríguez, Beatriz | - |
dc.creator | Rodríguez Rojas, Rafael | - |
dc.creator | Álamo, Marta del | - |
dc.creator | Obeso Martín, Ignacio | - |
dc.creator | Hernández-Fernández, Frida | - |
dc.creator | Trompeta, Clara | - |
dc.creator | Martínez-Fernández, Raúl | - |
dc.creator | Matarazzo, Michele | - |
dc.creator | Mata-Marín, David | - |
dc.creator | Guida, Pasqualina | - |
dc.creator | Duque, Alicia | - |
dc.creator | Albillo, David | - |
dc.creator | Plaza de las Heras, Isabel | - |
dc.creator | Montero Roblas, Juan Ignacio | - |
dc.creator | Foffani, Guglielmo | - |
dc.creator | Toltsis, Gabriella | - |
dc.creator | Rachmilevitch, Itay | - |
dc.creator | Blesa de los Mozos, Francisco Javier | - |
dc.creator | Obeso Inchausti, José Ángel | - |
dc.date.accessioned | 2024-02-05T14:42:02Z | - |
dc.date.available | 2024-02-05T14:42:02Z | - |
dc.date.issued | 2022-06-28 | - |
dc.identifier.citation | Pineda-Pardo JA, Gasca-Salas C, Fernández-Rodríguez B, Rodríguez-Rojas R, Del Álamo M, Obeso I, Hernández-Fernández F, Trompeta C, Martínez-Fernández R, Matarazzo M, Mata-Marín D, Guida P, Duque A, Albillo D, Plaza de Las Heras I, Montero JI, Foffani G, Toltsis G, Rachmilevitch I, Blesa J, Obeso JA. Striatal Blood-Brain Barrier Opening in Parkinson's Disease Dementia: A Pilot Exploratory Study. Mov Disord. 2022 Oct;37(10):2057-2065. doi: 10.1002/mds.29134. | es_ES |
dc.identifier.issn | 0885-3185 | - |
dc.identifier.uri | http://hdl.handle.net/10637/15350 | - |
dc.description.abstract | Background: Parkinson's disease (PD) exhibits a high prevalence of dementia as disease severity and duration progress. Focused ultrasound (FUS) has been applied for transient blood-brain barrier (BBB) opening of cortical regions in neurodegenerative disorders. The striatum is a primary target for delivery of putative therapeutic agents in PD. Objective: Here, we report a prospective, single-arm, nonrandomized, proof-of-concept, phase I clinical trial (NCT03608553 amended) in PD with dementia to test the safety and feasibility of striatal BBB opening in PD patients. Methods: Seven PD patients with cognitive impairment were treated for BBB opening in the posterior putamen. This was performed in two sessions separated by 2 to 4 weeks, where the second session included bilateral putamina opening in 3 patients. Primary outcome measures included safety and feasibility of focal striatal BBB opening. Changes in motor and cognitive functions, magnetic resonance imaging (MRI), 18 F-fluorodopa (FDOPA), and β-amyloid PET (positron emission tomography) images were determined. Results: The procedure was feasible and well tolerated, with no serious adverse events. No neurologically relevant change in motor and cognitive (battery of neuropsychological tests) functions was recognized at follow-up. MRI revealed putamen BBB closing shortly after treatment (24 hours to 14 days) and ruled out hemorrhagic and ischemic lesions. There was a discrete but significant reduction in β-amyloid uptake in the targeted region and no change in FDOPA PET. Conclusions: These initial results indicate that FUS-mediated striatal BBB opening is feasible and safe and therefore could become an effective tool to facilitate the delivery of putative neurorestorative molecules in PD. © 2022 International Parkinson and Movement Disorder Society. | en_EN |
dc.format | application/pdf | - |
dc.language.iso | en | - |
dc.publisher | Wiley | - |
dc.relation.ispartof | Movement Disorders | - |
dc.rights | http://creativecommons.org/licenses/by-nc-nd/4.0/deed.es | - |
dc.subject | Parkinson's disease | en_EN |
dc.subject | Focused ultrasound | en_EN |
dc.subject | Transient blood-brain barrier | en_EN |
dc.subject | Striatal neurons | en_EN |
dc.title | Striatal Blood–Brain Barrier Opening in Parkinson’s Disease Dementia: A Pilot Exploratory Study | en_EN |
dc.type | Artículo | es_ES |
dc.identifier.doi | 10.1002/mds.29134 | - |
dc.relation.projectID | Supported by Plan Nacional Ministerio de Educaci on y Ciencias PID2019 111045RB-I00 (Government of Spain), a grant from MAPFRE Foundation, and a joint project between Fundaci on Hospitales de Madrid and Insightec Ltd. Dr. Javier Blesa is currently funded by Instituto de Salud Carlos III Miguel Servet Program (CP19/00200) and FIS (PI20/00496). | - |
dc.centro | Universidad San Pablo-CEU | - |
Appears in Collections: | Medicina |
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