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Campo DC Valor Lengua/Idioma
dc.contributor.otherUniversidad San Pablo-CEU. Facultad de Medicina.-
dc.creatorAgache, Ioana-
dc.creatorBeltran, Jessica-
dc.creatorAkdis, Cezmi A.-
dc.creatorAkdis, Mubeccel-
dc.creatorCanelo Aybar, C.-
dc.creatorCanonica, Giorgio Walter-
dc.creatorCasale, Thomas-
dc.creatorChivato Pérez, Tomás-
dc.creatorCorren, Jonathan-
dc.creatorGiacco, Stefano del-
dc.creatorEiwegger, Thomas-
dc.creatorFirinu, Davide-
dc.creatorGern, James E.-
dc.creatorHamelmann, Eckard-
dc.creatorHanania, Nicola-
dc.creatorMäkelä, Mika-
dc.creatorHernández Martín, Irene-
dc.creatorO'Mahony, Liam-
dc.creatorPapi, Alberto-
dc.creatorPark, Hae-Sim-
dc.creatorPérez de Llano, Luis-
dc.creatorRocha, Claudio-
dc.creatorQuirce, Santiago-
dc.creatorSastre, Joaquín-
dc.creatorShamji, Mohamed-
dc.creatorSong, Yang-
dc.creatorSteiner, Corinna-
dc.creatorSchwarze, Jürgen-
dc.creatorAlonso Coello, Pablo-
dc.creatorPalomares, Oscar-
dc.creatorJutel, Marek-
dc.date.accessioned2024-01-26T11:30:14Z-
dc.date.available2024-01-26T11:30:14Z-
dc.date.issued2020-
dc.identifier.citationEfficacy and safety of treatment with biologicals (benralizumab, dupilumab, mepolizumab, omalizumab and reslizumab) for severe eosinophilic asthma. A systematic review for the EAACI Guidelines - recommendations on the use of biologicals in severe asthma. Allergy. 2020;75:1023– 1042. https ://doi.org/10.1111/all.14221en_EN
dc.identifier.issn1398-9995-
dc.identifier.urihttp://hdl.handle.net/10637/15129-
dc.description.abstractFive biologicals have been approved for severe eosinophilic asthma, a well-recognized phenotype. Systematic reviews (SR) evaluated the efficacy and safety of benralizumab, dupilumab, mepolizumab, omalizumab and reslizumab (alphabetical order) compared to standard of care for severe eosinophilic asthma. PubMed, Embase and Cochrane Library were searched to identify RCTs and health economic evaluations, published in English. Critical and important asthma-related outcomes were evaluated for each of the biologicals. The risk of bias and the certainty of the evidence were assessed using GRADE. 19 RCTs (three RCTs for benralizumab, three RCTs for dupilumab, three RCTs for mepolizumab, five RCTs for omalizumab and five RCTs for reslizumab), including subjects 12 to 75 years old (except for omalizumab including also subjects 6-11 years old), ranging from 12 to 56 weeks were evaluated. All biologicals reduce exacerbation rates with high certainty of evidence: benralizumab incidence rate ratio (IRR) 0.53 (95% CI 0.39 to 0.72), dupilumab (IRR) 0.43 (95% CI 0.32 to 0.59), mepolizumab IRR 0.49 (95% CI 0.38 to 0.66), omalizumab (IRR) 0.56 (95% CI 0.40 to 0.77) and reslizumab (IRR) 0.46 (95% CI 0.37 to 0.58). Benralizumab, dupilumab and mepolizumab reduce the daily dose of oral corticosteroids (OCS) with high certainty of evidence. All evaluated biologicals probably improve asthma control, QoL and FEV1, without reaching the minimal important difference (moderate certainty). Benralizumab, mepolizumab and reslizumab slightly increase drugrelated adverse events (AE) and drug-related serious AE (low to very low certainty of evidence). The incremental cost-effectiveness ratio per quality-adjusted life year value is above the willingness to pay threshold for all biologicals (moderate certainty). Potential savings are driven by decrease in hospitalizations, emergency and primary care visits. There is high certainty that all approved biologicals reduce the rate of severe asthma exacerbations and for benralizumab, dupilumab and mepolizumab for reducing OCS. There is moderate certainty for improving asthma control, QoL, FEV1. More data on long-term safety are needed together with more efficacy data in the paediatric population.en_EN
dc.formatapplication/pdf-
dc.language.isoenen_EN
dc.publisherWiley-
dc.relation.ispartofAllergy-
dc.rightshttp://creativecommons.org/licenses/by-nc-nd/4.0/deed.es-
dc.subjectBiologicalsen_EN
dc.subjectCost-effectivenessen_EN
dc.subjectEfficacyen_EN
dc.subjectSevere-eosinophilic-asthmaen_EN
dc.subjectSafetyen_EN
dc.titleEfficacy and safety of treatment with biologicals (benralizumab, dupilumab, mepolizumab, omalizumab and reslizumab) for severe eosinophilic asthma. A systematic review for the EAACI Guidelines - recommendations on the use of biologicals in severe asthma.en_EN
dc.typeArtículo-
dc.coverageNair, P.-
dc.coveragePapadopoulos, Nikolaos G.-
dc.coveragePosso, Margarita-
dc.identifier.doi10.1111/all.14221-
dc.centroUniversidad San Pablo-CEU-
Aparece en las colecciones: Medicina




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