Please use this identifier to cite or link to this item: http://hdl.handle.net/10637/15113
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dc.contributor.otherUCH. Departamento de Medicina y Cirugía Animal-
dc.contributor.otherProducción Científica UCH 2023-
dc.creatorBusechian, Sara-
dc.creatorConti, Maria Beatrice-
dc.creatorSgorbini, Micaela-
dc.creatorConte, Giuseppe-
dc.creatorMarchesi, Maria Chiara-
dc.creatorPieramati, Camillo-
dc.creatorZappulla, Francesco-
dc.creatorVitale, Valentina-
dc.creatorRueca, Fabrizio-
dc.date.accessioned2024-01-25T11:31:19Z-
dc.date.available2024-01-25T11:31:19Z-
dc.date.issued2023-07-
dc.identifier.citationBusechian, S., Conti, M.B., Sgorbini, M., Conte, G., Marchesi, M.C., Pieramati, C., Zappulla, F., Vitale, V. & Rueca, F. (2023). A comparison of the efficacy of two Omeprazole formulations in the treatment of Equine Gastric Ulcer Syndrome in racehorses: a blinded, randomized clinical trial. Journal of Equine Veterinary Science, vol. 126, art. 104296 (jul.). DOI: https://doi.org/10.1016/j.jevs.2023.104296es_ES
dc.identifier.issn0737-0806-
dc.identifier.urihttp://hdl.handle.net/10637/15113-
dc.description.abstractEquine gastric ulcer syndrome (EGUS) is the most common disease of the stomach in horses and treatment is based on the oral administration of omeprazole for at least 28 days. Aim of this study was to compare the efficacy of two formulations of oral omeprazole—powder paste and gastro-enteric resistant granules—in the treatment of naturally occurring gastric ulcers in racehorses. Thirty-two adult racehorses, aged between 2 and 10 years old, with clinical signs of EGUS were included in this blinded, randomized clinical trial. Two gastroscopies were performed to evaluate gastric lesions in the squamous or glandular mucosa before and after 28 days of treatment. After the first gastroscopy, 2/32 horses were excluded because affected by equine squamous gastric disease (ESGD) 1/4. The remaining horses were divided into 4 groups, and were treated with 2 formulations of omeprazole (gastroenteric resistant granules, group 1, or powder paste, group 3) or with 2 placebo formulations (granules, group 2, or paste, group 4). Treatments were performed in the placebo horses affected by ESGD or equine glandular gastric disease after the T28 gastroscopy control. No differences were found between groups at T0. Differences were found between T0 vs. T28 for granular (P = .002) and powder paste (P = .01) formulations. No differences were detected between the two groups receiving omeprazole formulations at T28 (0.34) and between T0 vs. T28 for either of the groups receiving placebo treatments. For all the variables, the size of the effect was greater than 0.5, proving that the treatments had a considerable effect. Gastro-enteric resistant granules and powder paste omeprazole showed similar efficacy in the treatment of ESGD. The glandular mucosa responded poorly to treatment with omeprazole.es_ES
dc.language.isoenes_ES
dc.publisherElsevieres_ES
dc.relation.ispartofJournal of Equine Veterinary Science, vol. 126-
dc.rightsOpen Access-
dc.rightshttp://creativecommons.org/licenses/by/4.0/deed.es-
dc.subjectMedicamentoes_ES
dc.subjectDrugses_ES
dc.subjectCaballoses_ES
dc.subjectHorseses_ES
dc.subjectEnfermedad animales_ES
dc.subjectAnimal diseaseses_ES
dc.subjectTerapiaes_ES
dc.subjectTherapyes_ES
dc.subjectSistema digestivoes_ES
dc.subjectDigestive systemses_ES
dc.titleA comparison of the efficacy of two Omeprazole formulations in the treatment of Equine Gastric Ulcer Syndrome in racehorses: a blinded, randomized clinical triales_ES
dc.typeArtículoes_ES
dc.identifier.doihttps://doi.org/10.1016/j.jevs.2023.104296-
dc.centroUniversidad Cardenal Herrera-CEU-
Appears in Collections:Dpto. Medicina y Cirugía Animal




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