Por favor, use este identificador para citar o enlazar este ítem: http://hdl.handle.net/10637/15090
Registro completo de metadatos
Campo DC Valor Lengua/Idioma
dc.contributor.otherUCH. Departamento de Producción y Sanidad Animal, Salud Pública Veterinaria y Ciencia y Tecnología de los Alimentos-
dc.creatorGarcía Párraga, Daniel-
dc.creatorLorenzo Bermejo, Teresa-
dc.creatorWang, Tobias-
dc.creatorOrtiz, José Luis-
dc.creatorOrtega Porcel, Joaquín-
dc.creatorCrespo Picazo, José Luis-
dc.creatorCortijo, Julio-
dc.creatorFahlman, Andreas-
dc.date.accessioned2024-01-24T12:04:07Z-
dc.date.available2024-01-24T12:04:07Z-
dc.date.issued2018-12-04-
dc.identifier.citationGarcía-Párraga, D., Lorenzo, T., Wang, T., Ortiz, J.L., Ortega, J., Crespo-Picazo, J.L., Cortijo, J. & Fahlman, A. (2018). Deciphering function of the pulmonary arterial sphincters in loggerhead sea turtles (Caretta caretta). The Journal of Experimental Biology, vol. 221, i. 23, art. jeb179820 (04 dec.). DOI: https://doi.org/10.1242/jeb.179820es_ES
dc.identifier.issn0022-0949-
dc.identifier.issn1477-9145 (Electrónico)-
dc.identifier.urihttp://hdl.handle.net/10637/15090-
dc.descriptionEste recurso no está disponible en acceso abierto por política de la editorial.-
dc.description.abstractTo provide new insight into the pathophysiological mechanisms underlying gas emboli (GE) in bycaught loggerhead sea turtles (Caretta caretta), we investigated the vasoactive characteristics of the pulmonary and systemic arteries, and the lung parenchyma (LP). Tissues were opportunistically excised from recently dead animals for in vitro studies of vasoactive responses to four different neurotransmitters: acetylcholine (ACh; parasympathetic), serotonin (5HT), adrenaline (Adr; sympathetic) and histamine. The significant amount of smooth muscle in the LP contracted in response to ACh, Adr and histamine. The intrapulmonary and systemic arteries contracted under both parasympathetic and sympathetic stimulation and when exposed to 5HT. However, proximal extrapulmonary arterial (PEPA) sections contracted in response to ACh and 5HT, whereas Adr caused relaxation. In sea turtles, the relaxation in the pulmonary artery was particularly pronounced at the level of the pulmonary artery sphincter (PASp), where the vessel wall was highly muscular. For comparison, we also studied tissue response in freshwater sliders turtles (Trachemys scripta elegans). Both PEPA and LP from freshwater sliders contracted in response to 5HT, ACh and also Adr. We propose that in sea turtles, the dive response (parasympathetic tone) constricts the PEPA, LP and PASp, causing a pulmonary shunt and limiting gas uptake at depth, which reduces the risk of GE during long and deep dives. Elevated sympathetic tone caused by forced submersion during entanglement with fishing gear increases the pulmonary blood flow causing an increase in N2 uptake, potentially leading to the formation of blood and tissue GE at the surface. These findings provide potential physiological and anatomical explanations on how these animals have evolved a cardiac shunt pattern that regulates gas exchange during deep and prolonged diving.es_ES
dc.language.isoenes_ES
dc.publisherThe Company of Biologistses_ES
dc.relationEste artículo de investigación ha sido financiado por la Office of Naval Research de los Estados Unidos de América (ONR YIP Award N000141410563).-
dc.relation.ispartofThe Journal of Experimental Biology, vol. 221, i. 23-
dc.rightshttps://creativecommons.org/licenses/by-nc-nd/4.0/deed.es-
dc.subjectTortugas marinases_ES
dc.subjectSea turtleses_ES
dc.subjectCirculación pulmonares_ES
dc.subjectPulmonary Circulationes_ES
dc.subjectPulmoneses_ES
dc.subjectLungses_ES
dc.subjectFisiologíaes_ES
dc.subjectPhysiologyes_ES
dc.titleDeciphering function of the pulmonary arterial sphincters in loggerhead sea turtles (Caretta caretta)es_ES
dc.typeArtículoes_ES
dc.identifier.doihttps://doi.org/10.1242/jeb.179820-
dc.centroUniversidad Cardenal Herrera-CEU-
Aparece en las colecciones: Dpto. Producción y Sanidad Animal, Salud Pública Veterinaria y Ciencia y Tecnología de los Alimentos




Los ítems de DSpace están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.