Por favor, use este identificador para citar o enlazar este ítem: http://hdl.handle.net/10637/14925
Registro completo de metadatos
Campo DC Valor Lengua/Idioma
dc.contributor.otherUCH. Departamento de Medicina y Cirugía-
dc.contributor.otherUCH. Departamento de Enfermería y Fisioterapia-
dc.creatorAbad Pérez, Pablo-
dc.creatorMolina Payá, Francisco Javier-
dc.creatorMartínez Otero, Luis-
dc.creatorBorrell, Víctor-
dc.creatorRedondo, Roger L.-
dc.creatorBrotons Mas, Jorge-
dc.date.accessioned2024-01-17T13:26:41Z-
dc.date.available2024-01-17T13:26:41Z-
dc.date.issued2023-05-21-
dc.identifier.citationAbad-Perez, P., Molina-Payá, F.J., Martínez-Otero, L., Borrell, V., Redondo, R.L. & Brotons-Mas, J.R. (2023). Theta/gamma co-modulation disruption after NMDAr blockade by MK-801 Is associated with spatial working memory deficits in mice. Neuroscience, vol. 519 (may.), pp. 162–176. DOI: https://doi.org/10.1016/j.neuroscience.2023.03.022es_ES
dc.identifier.issn0306-4522-
dc.identifier.urihttp://hdl.handle.net/10637/14925-
dc.description.abstractAbnormal N-methyl-D-aspartate receptor (NMDAr) function has been linked to oscillopathies, psychosis, and cognitive dysfunction in schizophrenia (SCZ). Here, we investigate the role of NMDAr hypofunction in pathological oscillations and behavior. We implanted mice with tetrodes in the dorsal/intermediate hippocampus and medial prefrontal cortex (mPFC), administered the NMDAr antagonist MK-801, and recorded oscillations during spontaneous exploration in an open field and in the y-maze spatial working memory test. Our results show that NMDAr blockade disrupted the correlation between oscillations and speed of movement, crucial for internal representations of distance. In the hippocampus, MK-801 increased gamma oscillations and disrupted theta/gamma coupling during spatial working memory. In the mPFC, MK-801 increased the power of theta and gamma, generated high-frequency oscillations (HFO 155–185 Hz), and disrupted theta/gamma coupling. Moreover, the performance of mice in the spatial working memory version of the y-maze was strongly correlated with CA1-PFC theta/gamma co-modulation. Thus, theta/gamma mediated by NMDAr function might explain several of SCZ’s cognitive symptoms and might be crucial to explaining hippocampal-PFC interaction.es_ES
dc.language.isoenes_ES
dc.publisherElsevieres_ES
dc.relationEste artículo de investigación ha sido financiado por la Agencia Estatal de Investigación a través del ‘Ministerio de Ciencia, Innovación y Universidades del Gobierno de España (RTI2018-097474-A-100).-
dc.relation.ispartofNeuroscience, vol. 519 (may.)-
dc.rightsOpen Access-
dc.rightshttp://creativecommons.org/licenses/by-nc-nd/4.0/deed.es-
dc.subjectPsicosis-
dc.subjectPsychoses-
dc.subjectEnfermedad mental-
dc.subjectMental diseases-
dc.subjectPsicopatología-
dc.subjectPsychopathology-
dc.titleTheta/gamma co-modulation disruption after NMDAr blockade by MK-801 Is associated with spatial working memory deficits in micees_ES
dc.typeArtículoes_ES
dc.identifier.doihttps://doi.org/10.1016/j.neuroscience.2023.03.022-
dc.relation.projectIDRTI2018-097474-A-100-
dc.centroUniversidad Cardenal Herrera-CEU-
Aparece en las colecciones: Dpto. Medicina y Cirugía




Los ítems de DSpace están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.