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dc.contributor.otherUCH. Departamento de Ciencias Biomédicas-
dc.contributor.otherUCH. Grupo de Investigación en Farmacia y Nutrición Clínica (CLINICPHARMA)-
dc.creatorPérez Ruixo, Carlos-
dc.creatorValenzuela, Belén-
dc.creatorPeris, José Esteban-
dc.creatorBretcha Boix, Pedro-
dc.creatorEscudero Ortiz, Vanesa-
dc.creatorFarré Alegre, José-
dc.creatorPérez Ruixo, Juan José-
dc.date.accessioned2024-01-16T12:45:43Z-
dc.date.available2024-01-16T12:45:43Z-
dc.date.issued2016-01-01-
dc.identifier.citationPérez-Ruixo, C., Valenzuela, B., Peris, J.E., Bretcha-Boix, P., Escudero-Ortiz, V., Farré-Alegre, J. & Pérez-Ruixo, J.J. (2016). Platelet dynamics in peritoneal carcinomatosis patients treated with cytoreductive surgery and hyperthermic intraperitoneal oxaliplatin. The AAPS Journal, vol. 18, i. 1 (01 en.), pp. 239–250. DOI: https://doi.org/10.1208/s12248-015-9839-0es_ES
dc.identifier.issn1550-7416-
dc.identifier.urihttp://hdl.handle.net/10637/14896-
dc.descriptionEste recurso no está disponible en acceso abierto por política de la editorial.-
dc.description.abstractThe aim of the study was to characterize the platelet count (PLT) dynamics in peritoneal carcinomatosis patients treated with cytoreductive surgery (CRS) and hyperthermic intraperitoneal oxaliplatin (HIO). Data from patients treated with CRS alone (N = 18) or CRS and HIO (N = 62) were used to estimate the baseline platelet count (PLT0), rate constants for platelet maturation (k tr ) and platelet random destruction (k s ), feedback on progenitor cell proliferation (γ), and the drug-specific model parameters (α, β). Plasma oxaliplatin concentrations, C p , reduced the proliferation rate of progenitor cells (k prol) according to a power function α × C p (β) . The surgery effect on k prol and k s was explored. The typical values (between subject variability) of the PLT0, k tr , k s , γ, α, and β were estimated to be 237 × 10(9) cells/L (32.9%), 7.09 × 10(-3) h(-1) (47.1%), 8.86 × 10(-3) h(-1) (80.0%), 0.621, 0.88 L/mg (56.9%), and 2.63. Surgery induced a maximal 2.09-fold increase in k prol that was attenuated with a half-life of 8.42 days. Splenectomy decreased k s by 47.5%. Age, sex, body surface area, sex, total proteins, and HIO carrier solution did not impact the model parameters. The model developed suggests that, following CRS and HIO, thrombocytopenia and thrombocytosis were reversible and short-lasting; the severity of the thrombocytopenia and thrombocytosis was inversely correlated, with splenectomized patients having thrombocytopenia of lower severity and thrombocytosis of higher severity; and the HIO dose and treatment duration determine the severity and duration of the thrombocytopenia. Higher HIO dose or longer treatment duration could be used without substantially increasing the risk of major hematological toxicity.es_ES
dc.language.isoenes_ES
dc.publisherSpringer Naturees_ES
dc.relationEste artículo de investigación ha sido financiado por la Consellería de Sanidad de la Generalitat Valenciana (GE-079/11).-
dc.relation.ispartofThe AAPS Journal, vol. 18, i. 1 (01 en.)-
dc.rightshttp://creativecommons.org/licenses/by-nc-nd/4.0/deed.es-
dc.subjectCáncer-
dc.subjectCancer-
dc.subjectMedicamento-
dc.subjectDrugs-
dc.subjectTratamiento médico-
dc.subjectMedical treatment-
dc.subjectCirugía-
dc.subjectSurgery-
dc.titlePlatelet dynamics in peritoneal carcinomatosis patients treated with cytoreductive surgery and hyperthermic intraperitoneal oxaliplatines_ES
dc.typeArtículoes_ES
dc.identifier.doihttps://doi.org/10.1208/s12248-015-9839-0-
dc.relation.projectIDGE-079/11-
dc.centroUniversidad Cardenal Herrera-CEU-
Aparece en las colecciones: Dpto. Ciencias Biomédicas




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