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Connection between mesenchymal stem cells therapy and osteoclasts in osteoarthritis


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Title: Connection between mesenchymal stem cells therapy and osteoclasts in osteoarthritis
metadata.dc.creator: Ibáñez Torres, Lidia.
Guillem Llobat, Paloma.
Marín Vázquez, Marta.
Guillén Salazar, María Isabel.
Keywords: Osteoarthritis - Treatment.Stem cells - Therapeutic use.Células madre - Uso terapéutico.Osteoartritis - Tratamiento.
Publisher: MDPI
Citation: Ibáñez, L., Guillem-Llobat, P., Marín, M. & Guillén, M. I. (2022). Connection between mesenchymal stem cells therapy and osteoclasts in osteoarthritis. International Journal of Molecular Sciences, vol. 23, i. 9 (23 apr.), art. 4693. DOI:
Abstract: The use of mesenchymal stem cells constitutes a promising therapeutic approach, as it has shown beneficial effects in different pathologies. Numerous in vitro, pre-clinical, and, to a lesser extent, clinical trials have been published for osteoarthritis. Osteoarthritis is a type of arthritis that affects diarthritic joints in which the most common and studied effect is cartilage degradation. Nowadays, it is known that osteoarthritis is a disease with a very powerful inflammatory component that affects the subchondral bone and the rest of the tissues that make up the joint. This inflammatory component may induce the differentiation of osteoclasts, the bone-resorbing cells. Subchondral bone degradation has been suggested as a key process in the pathogenesis of osteoarthritis. However, very few published studies directly focus on the activity of mesenchymal stem cells on osteoclasts, contrary to what happens with other cell types of the joint, such as chondrocytes, synoviocytes, and osteoblasts. In this review, we try to gather the published bibliography in relation to the effects of mesenchymal stem cells on osteoclastogenesis. Although we find promising results, we point out the need for further studies that can support mesenchymal stem cells as a therapeutic tool for osteoclasts and their consequences on the osteoarthritic joint.
Description: Este artículo se encuentra disponible en la siguiente URL:
Este artículo de investigación pertenece al número especial "New Sources, Differentiation, and Therapeutic Uses of Mesenchymal Stem Cells 2.0".
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ISSN: 1422-0067 (Electrónico)
Language: es
Issue Date: 23-Apr-2022
Center : Universidad Cardenal Herrera-CEU
Appears in Collections:Dpto. Farmacia

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