Por favor, use este identificador para citar o enlazar este ítem:
http://hdl.handle.net/10637/14178
Registro completo de metadatos
Campo DC | Valor | Lengua/Idioma |
---|---|---|
dc.contributor.other | Producción Científica UCH 2022 | - |
dc.contributor.other | UCH. Departamento de Producción y Sanidad Animal, Salud Pública Veterinaria y Ciencia y Tecnología de los Alimentos | - |
dc.creator | Álvarez Fernández, Luis | - |
dc.creator | Marín García, Pablo Jesús | - |
dc.creator | Rentero Garrido, Pilar | - |
dc.creator | Llobat Bordes, Lola | - |
dc.date | 2022 | - |
dc.date.accessioned | 2023-03-28T04:00:42Z | - |
dc.date.available | 2023-03-28T04:00:42Z | - |
dc.date.issued | 2022-11-02 | - |
dc.identifier.citation | Álvarez, L., Marín-García, P. J., Rentero-Garrido, P. & Llobat, L. (2022). Immune and genomic analysis of Boxer dog breed and Its relationship with "Leishmania infantum" infection. Veterinary Sciences, vol. 9, i. 11 (02 nov.), art. 608. DOI: https://doi.org/10.3390/vetsci9110608 | - |
dc.identifier.issn | 2306-7381 (Electrónico) | - |
dc.identifier.uri | http://hdl.handle.net/10637/14178 | - |
dc.description | Este artículo se encuentra disponible en la siguiente URL: https://www.mdpi.com/2306-7381/9/11/608 | - |
dc.description | Este artículo pertenece al número especial "Parasitology Research: Surveillance Pathogens and Its Mechanism". | - |
dc.description.abstract | Leishmaniosis, one of themost important zoonoses in Europe, is caused by Leishmania infantum, an intracellular protozoan parasite. This disease is endemic in theMediterranean area, where the main reservoir is the dog. Several studies indicate a possible susceptibility to L. infantum infection with clinical signs in some canine breeds. One of them is the boxer breed, which shows a high prevalence of disease. In this study, immunological and genomic characterization of serum samples from boxer dogs living in theMediterranean area were evaluated to analyze the immune response and the possible genetic explanation for this susceptibility. Serum levels of cytokines IFN- , IL-2, IL-6, IL-8, and IL-18 were determined by ELISA commercial tests, while the genotyping study was performed using the CanineHD DNA Analysis BeadChip. The results show relevant differences in the serum levels of cytokines compared to published data on other canine breeds, as well as sequence changes that could explain the high susceptibility of the boxer breed to the disease. Concretely, polymorphic variants in the CIITA, HSF2BP, LTBP1,MITF, NOXA1, PKIB, RAB38, RASEF, TLE1, and TLR4 genes were found, which could explain the susceptibility of this breed to L. infantum infection. | - |
dc.format | application/pdf | - |
dc.language | es | - |
dc.language.iso | en | - |
dc.publisher | MDPI | - |
dc.relation | Este artículo de investigación ha sido financiado por una becas de Grupos Emergentes de Investigación de la Generalitat Valenciana (GV/2021/104) y de la Universidad CEU Cardenal Herrera (IDOC21-03). | - |
dc.relation | UCH. Financiación Autonómica | - |
dc.relation | UCH. Financiación Universidad | - |
dc.relation.ispartof | Veterinary Sciences, vol. 9, i. 11 (02 nov. 2022) | - |
dc.rights | http://creativecommons.org/licenses/by/4.0/deed.es | - |
dc.subject | Dogs - Communicable diseases. | - |
dc.subject | Leishmaniasis in dogs. | - |
dc.subject | Leishmaniasis en los perros. | - |
dc.subject | Perros - Enfermedades infecciosas. | - |
dc.title | Immune and genomic analysis of Boxer dog breed and its relationship with "Leishmania infantum" infection | - |
dc.type | Artículo | - |
dc.identifier.doi | https://doi.org/10.3390/vetsci9110608 | - |
dc.relation.projectID | GV/2021/104 | - |
dc.relation.projectID | IDOC21-03 | - |
dc.centro | Universidad Cardenal Herrera-CEU | - |
Aparece en las colecciones: | Dpto. Producción y Sanidad Animal, Salud Pública Veterinaria y Ciencia y Tecnología de los Alimentos |
Los ítems de DSpace están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.