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Título : Role of hippocampal NF-kappa B and GluN2B in the memory acquisition impairment of experiences gathered prior to cocaine administration in rats
Autor : López Pedrajas, Rosa María.
Almansa Frías, María Inmaculada.
Sánchez Villarejo, María Victoria.
Muriach Saurí, Borja.
Barcia González, Jorge Miguel.
Romero Gómez, Francisco Javier.
Muriach Saurí, María.
Materias: Sistema nervioso - Enfermedades.Neurosciences.Neurociencias.Cocaine consumption - Physiological effect.Memory disorders.Cocaína - Consumo - Efectos fisiológicos.Nervous system - Diseases.Memoria - Trastornos.
Fecha de publicación : 8-oct-2021
Editorial : Nature Research
Citación : López-Pedrajas, R., Almansa, I., Sánchez-Villarejo, M.V., Muriach, B., Barcia, J.M., Romero, F.J. & Muriach, M. (2021). Role of hippocampal NF-κB and GluN2B in the memory acquisition impairment of experiences gathered prior to cocaine administration in rats. Scientific Reports, vol. 11, art. 20033 (08 oct.). DOI: https://doi.org/10.1038/s41598-021-99448-w
Resumen : Cocaine can induce severe neurobehavioral changes, among others, the ones involved in learning and memory processes. It is known that during drug consumption, cocaine-associated memory and learning processes take place. However, much less is known about the effects of this drug upon the mechanisms involved in forgetting.The present report focuses on the mechanisms by which cocaine affects memory consolidation of experiences acquired prior to drug administration. We also study the involvement of hippocampus in these processes, with special interest on the role of Nuclear factor kappa B (NF-κB), N-methyl-D-aspartate glutamate receptor 2B (GluN2B), and their relationship with other proteins, such as cyclic AMP response element binding protein (CREB). For this purpose, we developed a rat experimental model of chronic cocaine administration in which spatial memory and the expression or activity of several proteins in the hippocampus were assessed after 36 days of drug administration. We report an impairment in memory acquisition of experiences gathered prior to cocaine administration, associated to an increase in GluN2B expression in the hippocampus. We also demonstrate a decrease in NF-κB activity, as well as in the expression of the active form of CREB, confirming the role of these transcription factors in the cocaine-induced memory impairment.
Descripción : Este artículo se encuentra disponible en la siguiente URL: https://www.nature.com/articles/s41598-021-99448-w.pdf
Idioma: en
URI : http://hdl.handle.net/10637/13693
Derechos: http://creativecommons.org/licenses/by/4.0/deed.es
ISSN : 2045-2322 (Electrónico)
Aparece en las colecciones: Dpto. Ciencias Biomédicas

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