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Prepulse inhibition in cocaine addiction and dual pathologies


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Título : Prepulse inhibition in cocaine addiction and dual pathologies
Autor : Gil Miravet, Isis
Fuertes Saiz, Alejandro
Benito, Ana
Almodóvar Fernández, Isabel
Ochoa de Aranda, Enrique
Haro Cortés, Gonzalo Rafael
Materias: Psicopatología.Psychology, Pathological.Cocaína - Adicción.Cocaine abuse.Trastorno de personalidad antisocial - Diagnóstico.Schizophrenia - Diagnosis.Personality disorders - Diagnosis.Antisocial personality disorder - Diagnosis.Personalidad - Trastornos - Diagnóstico.Esquizofrenia - Diagnóstico.
Editorial : MDPI
Citación : Gil-Miravet, I., Fuertes-Saiz, A., Benito, A., Almodóvar, I., Ochoa, E. & Haro, G. (2021). Prepulse inhibition in cocaine addiction and dual pathologies. Brain Sciences, vol. 11, i. 2 (20 feb.), art. 269. DOI: https://doi.org/10.3390/brainsci11020269
Resumen : Cocaine addiction is frequently associated with different psychiatric disorders, especially schizophrenia and antisocial personality disorder. A small number of studies have used prepulse inhibition (PPI) as a discriminating factor between these disorders. This work evaluated PPI and the phenotype of patients with cocaine-related disorder (CRD) who presented a dual diagnosis of schizophrenia or antisocial personality disorder. A total of 74 men aged 18–60 years were recruited for this research. The sample was divided into four groups: CRD (n = 14), CRD and schizophrenia (n = 21), CRD and antisocial personality disorder (n = 16), and a control group (n = 23). We evaluated the PPI and other possible vulnerability factors in these patients by using different assessment scales. PPI was higher in the CRD group at 30 ms (F(3, 64) = 2.972, p = 0.038). Three discriminant functions were obtained which allowed us to use the overall Hare Psychopathy Checklist Revised score, reward sensitivity, and PPI at 30 ms to predict inclusion of these patients in the different groups with a success rate of 79.7% (42.9% for CRD, 76.2% for CRD and schizophrenia, 100% for CRD and antisocial personality disorder, and 91.3% in the control group). Despite the differences we observed in PPI, this factor is of little use for discriminating between the different diagnostic groups and it acts more as a non-specific endophenotype in certain mental disorders, such as in patients with a dual diagnosis.
Descripción : Este artículo se encuentra disponible en la siguiente URL: https://www.mdpi.com/2076-3425/11/2/269
Este artículo de investigación pertenece a la sección "Systems Neuroscience".
URI : http://hdl.handle.net/10637/13607
Derechos: http://creativecommons.org/licenses/by/4.0/deed.es
ISSN : 2076-3425 (Electrónico)
Fecha de publicación : 20-feb-2021
Centro : Universidad Cardenal Herrera-CEU
Aparece en las colecciones: Dpto. Medicina y Cirugía





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