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Cell and cell free therapies in osteoarthritis


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Title: Cell and cell free therapies in osteoarthritis
Authors : Peláez Gorrea, Pau
Damiá Giménez, Elena
Torres Torrillas, Marta
Chicharro Alcántara, Deborah
Cuervo Serrato, Belén
Miguel Pastor, Laura
Romero Martínez, Ayla del
Carrillo Poveda, José María.
Sopena Juncosa, Joaquín Jesús.
Rubio Zaragoza, Mónica.
Keywords: Osteoartritis - Tratamiento.Crecimiento - Factores - Uso terapéutico.Plasma sanguíneo - Uso terapéutico.Stem cells - Therapeutic use.Growth factors - Therapeutic use.Osteoarthritis - Treatment.Células madre - Uso terapéutico.Blood plasma - Therapeutic use.
Publisher: MDPI
Citation: Peláez, P., Damiá, E., Torres-Torrillas, M., Chicharro, D., Cuervo, B., Miguel, L., Del Romero, A., Carrillo, J.M., Sopena, J.J. & Rubio, M. (2021). Cell and cell free therapies in osteoarthritis. Biomedicines, vol. 9, i. 11 (19 nov.), art. 1726. DOI: https://doi.org/10.3390/biomedicines9111726
Abstract: Osteoarthritis (OA) is the most common articular disease in adults and has a current prevalence of 12% in the population over 65 years old. This chronic disease causes damage to articular cartilage and synovial joints, causing pain and leading to a negative impact on patients’ function, decreasing quality of life. There are many limitations regarding OA conventional therapies—pharmacological therapy can cause gastrointestinal, renal, and cardiac adverse effects, and some of them could even be a threat to life. On the other hand, surgical options, such as microfracture, have been used for the last 20 years, but hyaline cartilage has a limited regeneration capacity. In recent years, the interest in new therapies, such as cell-based and cell-free therapies, has been considerably increasing. The purpose of this review is to describe and compare bioregenerative therapies’ efficacy for OA, with particular emphasis on the use of mesenchymal stem cells (MSCs) and platelet-rich plasma (PRP). In OA, these therapies might be an alternative and less invasive treatment than surgery, and a more effective option than conventional therapies.
Description: Este artículo se encuentra disponible en la siguiente URL: https://www.mdpi.com/2227-9059/9/11/1726
Este artículo pertenece al número especial "Adipose-Derived Mesenchymal Stem Cells, Cell-Based Therapies, and Biomaterials as New Regenerative Strategies".
URI: http://hdl.handle.net/10637/13495
Rights : http://creativecommons.org/licenses/by/4.0/deed.es
ISSN: 2227-9059 (Electrónico)
Issue Date: 19-Nov-2021
Center : Universidad Cardenal Herrera-CEU
Appears in Collections:Dpto. Medicina y Cirugía Animal





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