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Effects of oral hyaluronic acid administration in dogs following tibial tuberosity advancement surgery for cranial cruciate ligament injury


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Título : Effects of oral hyaluronic acid administration in dogs following tibial tuberosity advancement surgery for cranial cruciate ligament injury
Autor : Serra Aguado, Claudio Iván
Ramos Plá, Juan José
Soler i Canet, María del Carme
Segarra, Sergi
Moratalla, Víctor
Redondo García, José Ignacio
Materias: Ácido hialurónico - Uso terapéutico.Hyaluronic acid - Therapeutic use.Osteoartritis en los perros - Tratamiento.Ligaments - Surgery.Ligamentos - Cirugía.Osteoarthritis in dogs.Perros - Cirugía.Dogs - Surgery.
Editorial : MDPI
Citación : Serra Aguado, C.I., Ramos-Plá, J.J., Soler, C., Segarra, S., Moratalla, V. & Redondo, J.I. (2021). Effects of oral hyaluronic acid administration in dogs following tibial tuberosity advancement surgery for cranial cruciate ligament injury. Animals, vol. 11, i. 5 (27 apr.), art. 1264. DOI: https://doi.org/10.3390/ani11051264
Resumen : Hyaluronic acid (HA) intraarticular injection is used in the management of osteoarthritis in veterinary medicine. However, HA oral administration is less common given the scarce currently available scientific evidence. This study was aimed at evaluating the effects of oral HA administration on synovial fluid concentrations of several selected biomarkers in dogs with cranial cruciate ligament (CCL) injury operated on using the tibial tuberosity advancement (TTA) technique. Fifty-five dogs were included in this prospective, randomized, double-blind, clinical study; they were randomly assigned to receive either a placebo (group A; n = 25) or HA (group B; n = 30) orally for 10 weeks. Synovial fluid samples were obtained before surgery, and at 10 weeks postoperatively to measure concentrations of HA, haptoglobin, nitric oxide, and paraoxonase-1. After 10 weeks, group HA showed a significant increase in HA concentration (p = 0.0016) and a significant decrease in PON-1 concentration (p = 0.011) compared to baseline. In conclusion, post-op oral HA administration in canine patients with CCL injury leads to improvements in osteoarthritis biomarkers, namely higher synovial fluid HA concentrations and reduced synovial fluid paraoxonase-1 concentrations. These findings support the bioavailability of orally-administered HA and its usefulness in improving biomarkers of osteoarthritis.
Descripción : Este artículo se encuentra disponible en la siguiente URL: https://www.mdpi.com/2076-2615/11/5/1264
Este artículo pertenece a la sección "Veterinary Clinical Studies".
URI : http://hdl.handle.net/10637/13452
Derechos: http://creativecommons.org/licenses/by/4.0/deed.es
ISSN : 2076-2615 (Electrónico)
Fecha de publicación : 27-abr-2021
Centro : Universidad Cardenal Herrera-CEU
Aparece en las colecciones: Dpto. Medicina y Cirugía Animal





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